[辽宁省健康人群中通过血清杀菌试验检测抗C群脑膜炎奈瑟菌抗体]

[Testing of antibodies against serogroup C Neisseria meningitidis by serum bactericidal assay in healthy population, Liaoning province].

作者信息

An Shu-Yi, Xu Li, Li Yi-Xing

机构信息

Liaoning Provincial Center for Disease Control and Prevention, Shenyang 110005, Liaoning, China.

出版信息

Zhongguo Yi Miao He Mian Yi. 2009 Oct;15(5):456-8.

PMID:20084976

Abstract

OBJECTIVE

To test the serum antibodies from healthy population by Serum Bactericidal Assay (SBA), in order to evaluate the level of protective antibodies against serogroup C Neisseria meningitidis in Liaoning province.

METHODS

240 serum samples were selected from eight age-group randomly. Serogroup C vaccine candidate strain (C11) and the prevail serogroup C strain (053442) were used for SBA.

RESULTS

48.33% of 240 serum samples were positive (titer > or = 1:2) to C11 vaccine strain. Protective rate of SBA was 35.83% (titer > or = 1:8), in which, > or = 6 years old were 13.33%, 7-19 years old was 61.67%, 20-39 years old were 46.67% and > or = 40 years old were 63.33%. Rate of SBA to 053442 was lower than that to C11 in the group over 15 years old by statistic analysis.

CONCLUSION

Population under 6 years old showed lower SBA capacities. With the implemention of Expanded Program on Immunization, children under 3 years old should be considered how to give them meningococcal vaccine in order to improve the titer of antibodies against Neisseria meningitidis serogroup C.

摘要

目的

采用血清杀菌试验（SBA）检测健康人群血清抗体，以评估辽宁省人群抗C群脑膜炎奈瑟菌保护性抗体水平。

方法

随机选取8个年龄组的240份血清样本。采用C群疫苗候选菌株（C11）和流行的C群菌株（053442）进行SBA检测。

结果

240份血清样本中，48.33%对C11疫苗株呈阳性（滴度≥1:2）。SBA保护率为35.83%（滴度≥1:8），其中，≥6岁人群为13.33%，7 - 19岁人群为61.67%，20 - 39岁人群为46.67%，≥40岁人群为63.33%。经统计学分析，15岁以上人群对053442的SBA率低于对C11的SBA率。