Karakoc Derya, Sayek Iskender
Department of General Surgery, Hacettepe University Medical School, Sihhiye, Ankara, Turkey.
Int Surg. 2008 Nov-Dec;93(6):346-53.
The mortality rate of intra-abdominal infections is high, and new prognostic factors are being investigated. Tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 are among these factors. Intraoperative peritoneal lavage is part of surgical treatment for intra-abdominal infection. The aim of this study is to investigate the effect of peritoneal lavage on TNF-alpha, IL-1beta, and IL-6 levels and mortality when the source control has or has not been established. Eighty-five rats were divided into control, cecal ligation and puncture, and cecal ligation and puncture with excision groups. The effect of peritoneal lavage on TNF-alpha, IL-1beta, and IL-6 levels and mortality could not be shown in this study.
腹腔内感染的死亡率很高，新的预后因素正在研究中。肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-1β和IL-6就是这些因素之一。术中腹腔灌洗是腹腔内感染手术治疗的一部分。本研究的目的是探讨在感染源已控制或未控制的情况下，腹腔灌洗对TNF-α、IL-1β和IL-6水平及死亡率的影响。85只大鼠分为对照组、盲肠结扎穿刺组和盲肠结扎穿刺切除组。本研究未能显示腹腔灌洗对TNF-α、IL-1β和IL-6水平及死亡率的影响。
