Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2009 Nov-Dec;13(6):419-23.
Gastrointestinal motility disorders are often present in diabetic patients (pts). Such motility dysfunctions have been attributed to autonomic neuropathy. Impaired intestinal motility is often associated with small-bowel bacterial overgrowth (SIBO) but only few studies evaluated the relationship between autonomic neuropathy and SIBO in diabetic pts.
To compare the prevalence of SIBO between type 1 diabetic (T1D) pts with and without autonomic neuropathy.
25 pts (13 males, 12 females; mean age 44.2+/-7) affected by type 1 diabetes with normal cardiovascular autonomic test (group A) and 25 type 1 diabetic pts with abnormal cardiovascular autonomic test (group B) were submitted to hydrogen lactulose breath test.
2 out of 25 (8%) showed SIBO among group A, while 11 out of 25 (44%) showed SIBO among group B (p<0.01). Interestingly, among group B, the daily insulin requirements was significantly higher in SIBO-positive pts compared to SIBO-negative: 0.66+/-0.3 vs. 0.59+/-0.1 UI/kg (p<0.05).
Pts with autonomic neuropathy have a significantly higher prevalence of SIBO, that is also associated with a higher daily insulin requirements.
胃肠道动力障碍在糖尿病患者（pts）中经常出现。这种运动功能障碍归因于自主神经病变。肠道蠕动功能障碍常与小肠细菌过度生长（SIBO）有关，但只有少数研究评估了糖尿病患者自主神经病变与 SIBO 之间的关系。
比较 1 型糖尿病（T1D）伴或不伴自主神经病变患者 SIBO 的患病率。
25 例 T1D 患者（男 13 例，女 12 例；平均年龄 44.2+/-7 岁），心血管自主神经测试正常（A 组）和 25 例 T1D 患者心血管自主神经测试异常（B 组）进行氢乳果糖呼气试验。
A 组有 2 例（8%）出现 SIBO，B 组有 11 例（44%）出现 SIBO（p<0.01）。有趣的是，在 B 组中，SIBO 阳性患者的每日胰岛素需求量明显高于 SIBO 阴性患者：0.66+/-0.3 vs. 0.59+/-0.1 UI/kg（p<0.05）。
伴自主神经病变的患者 SIBO 患病率明显较高，且与每日胰岛素需求量增加相关。
