Lobachevskiĭ P N, Fominykh E V
Radiobiologiia. 1991 Jan-Feb;31(1):59-64.
The possible influence of a radiation-induced delay of cell division on the yield of chromosome aberrations has been analyzed theoretically. The analysis is based on the assumption that the delay is caused by the damages that are realized in the mitosis as chromosome aberrations. It has been shown that the distributions of cells, that are registered by the number of chromosome aberrations, are a function of time of cell fixation and may substantially differ from actual disturbance. There is a correlation between the registered and actual disturbances which is determined by the kinetics of the first mitosis of nonirradiated cells and the degree of the radiation-induced division delay. Some qualitative sequels of the proposed model are in agreement with the experimental data.
理论上分析了辐射诱导的细胞分裂延迟对染色体畸变产率的可能影响。该分析基于这样的假设，即延迟是由在有丝分裂中作为染色体畸变而显现的损伤所引起的。结果表明，按染色体畸变数量记录的细胞分布是细胞固定时间的函数，并且可能与实际干扰有很大差异。记录的干扰与实际干扰之间存在相关性，这由未受辐射细胞的首次有丝分裂动力学和辐射诱导的分裂延迟程度决定。所提出模型的一些定性结果与实验数据相符。
