Vladimirov V G, Chigareva N G, Sharova L A
Radiobiologiia. 1991 Jan-Feb;31(1):77-81.
In experiments with dogs and monkeys a study was made of the dynamics of the content of prostaglandins (PG) and cyclic nucleotides after gamma irradiation. In dogs irradiation with lethal doses (3.1 and 50 Gy) caused a short-term, evidently stress growth of cAMP, PGE and PGF2 alpha levels. At the height of radiation sickness PGF2 alpha and cGMP content decreased considerably. Irradiation of monkeys with a nonlethal dose of 3.2 Gy changed PGE and PGF2 alpha levels to a lesser extent, while concentrations of cyclic nucleotides varied but their ratio remained stable.
在对狗和猴子进行的实验中，研究了γ射线照射后前列腺素（PG）和环核苷酸含量的动态变化。在狗身上，致死剂量（3.1和50 Gy）的照射导致cAMP、PGE和PGF2α水平出现短期、明显的应激性升高。在放射病高峰期，PGF2α和cGMP含量大幅下降。用3.2 Gy的非致死剂量照射猴子，PGE和PGF2α水平变化较小，而环核苷酸浓度有所变化但其比例保持稳定。
