Abesadze A I, Glonti A O, Akhmeteli L I
Patol Fiziol Eksp Ter. 1991 May-Jun(3):32-4.
The authors studied changes in the content of groups E and F2 prostaglandins (PGE and PGF2) and cyclic nucleotides (cAMP and cGMP) in blood of dogs after 20 ml/kg blood loss as well as in transfusion of whole blood, plasma and 10 ml/kg packed erythrocytes after preliminary blood letting. It was established that after loss of blood the concentration of PGE, cAMP and cGMP increases while the concentration of PGF2 in the blood reduces. It is also shown that transfusion of whole blood facilitates correction of the content of prostaglandins and cyclic nucleotides in the blood. The posthemorrhagic changes of most of the studied indices are normalized in the 24 hours after transfusion of packed erythrocytes, transfusion of plasma fails to correct the revealed shifts.
作者研究了犬失血量为20 ml/kg后以及在预先放血后输注全血、血浆和10 ml/kg浓缩红细胞后，血液中E组和F2组前列腺素（PGE和PGF2）以及环核苷酸（cAMP和cGMP）含量的变化。结果发现，失血后血液中PGE、cAMP和cGMP的浓度升高，而PGF2的浓度降低。还表明，输注全血有助于纠正血液中前列腺素和环核苷酸的含量。输注浓缩红细胞后24小时内，大多数研究指标的出血后变化恢复正常，而输注血浆未能纠正所发现的变化。
