Nordic Bioscience A/S, Herlev, Denmark.
Biomarkers. 2010 Feb;15(1):1-19. doi: 10.3109/13547500903295873.
Osteoarthritis is a chronic disease for which no efficacious medical intervention is yet available. Recent disappointments in late-stage clinical development of disease-modifying osteoarthritic drugs (DMOADs) have precipitated efforts in biomarker discovery aimed at developing an analytical tool box with the potential to improve the clinical development process. In this review, we seek to provide an overview of the biochemical marker repertoire currently available with a special focus on data originating from their application in clinical development programmes. Finally, we discuss possible directions in future biomarker research.
骨关节炎是一种慢性疾病，目前尚无有效的医学干预措施。最近，疾病修饰性骨关节炎药物（DMOAD）在晚期临床开发中的令人失望，促使人们努力发现生物标志物，旨在开发一个具有潜在改善临床开发过程的分析工具包。在这篇综述中，我们旨在提供目前可用的生化标志物谱的概述，特别关注源自其在临床开发计划中的应用的数据。最后，我们讨论了未来生物标志物研究的可能方向。
