骨髓病变的发展与膝关节软骨的不良影响有关，而其消退与改善有关——这可能是预防膝关节骨关节炎的一个靶点：一项纵向研究。

Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement--a potential target for prevention of knee osteoarthritis: a longitudinal study.

机构信息

Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia.

出版信息

Arthritis Res Ther. 2010;12(1):R10. doi: 10.1186/ar2911. Epub 2010 Jan 19.

DOI:10.1186/ar2911

PMID:20085624

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2875638/

Abstract

INTRODUCTION

To examine the relationship between development or resolution of bone marrow lesions (BMLs) and knee cartilage properties in a 2 year prospective study of asymptomatic middle-aged adults.

METHODS

271 adults recruited from the Melbourne Collaborative Cohort Study, underwent a magnetic resonance imaging scan (MRI) of their dominant knee at baseline and again approximately 2 years later. Cartilage volume, cartilage defects and BMLs were determined at both time points.

RESULTS

Among 234 subjects free of BMLs at baseline, 33 developed BMLs over 2 years. The incidence of BMLs was associated with progression of tibiofemoral cartilage defects (OR 2.63 (95% CI 0.93, 7.44), P = 0.07 for medial compartment; OR 3.13 (95% CI 1.01, 9.68), P = 0.048 for lateral compartment). Among 37 subjects with BMLs at baseline, 17 resolved. Resolution of BMLs was associated with reduced annual loss of medial tibial cartilage volume (regression coefficient -35.9 (95%CI -65, -6.82), P = 0.02) and a trend for reduced progression of medial tibiofemoral cartilage defects (OR 0.2 (95% CI 0.04, 1.09), P = 0.06).

CONCLUSIONS

In this cohort study of asymptomatic middle-aged adults the development of new BMLs was associated with progressive knee cartilage pathology while resolution of BMLs prevalent at baseline was associated with reduced progression of cartilage pathology. Further work examining the relationship between changes and BML and cartilage may provide another important target for the prevention of knee osteoarthritis.

摘要

介绍

在一项针对无症状中年成年人的为期 2 年的前瞻性研究中，研究了骨髓病变（BML）的发展或缓解与膝关节软骨特性之间的关系。

方法

从墨尔本合作队列研究中招募了 271 名成年人，在基线时和大约 2 年后对他们的优势膝关节进行了磁共振成像（MRI）扫描。在这两个时间点都确定了软骨体积、软骨缺陷和 BML。

结果

在基线时无 BML 的 234 名受试者中，有 33 名在 2 年内出现了 BML。BML 的发生率与胫骨股骨软骨缺陷的进展有关（内侧间室的优势比为 2.63（95%CI 0.93,7.44），P = 0.07；外侧间室为 3.13（95%CI 1.01,9.68），P = 0.048）。在基线时有 BML 的 37 名受试者中，有 17 名得到了缓解。BML 的缓解与内侧胫骨软骨体积的年损失减少有关（回归系数-35.9（95%CI-65，-6.82），P = 0.02），并且内侧胫骨股骨软骨缺陷的进展呈下降趋势（优势比 0.2（95%CI 0.04，1.09），P = 0.06）。