艾尔，多面手。
Aire, master of many trades.
机构信息
Division of Developmental Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg 69120, Germany.
出版信息
Cell. 2010 Jan 8;140(1):24-6. doi: 10.1016/j.cell.2009.12.036.
PMID:20085700
Abstract
In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.
摘要
在胸腺上皮细胞中，蛋白 Aire（自身免疫调节因子）诱导数百种外周组织抗原的异位表达，从而扩大了可用于诱导中枢 T 细胞耐受的抗原谱。通过分析 Aire 的相互作用伙伴，Abramson 等人（2010 年）为这种非传统形式的基因表达提供了新的线索。
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