用维生素 C 为重编程供能。

Powering reprogramming with vitamin C.

机构信息

Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.

出版信息

Cell Stem Cell. 2010 Jan 8;6(1):1-2. doi: 10.1016/j.stem.2009.12.012.

DOI:10.1016/j.stem.2009.12.012

PMID:20085733

Abstract

In this issue of Cell Stem Cell, Esteban et al. (2009) report that vitamin C enhances the reprogramming efficiency of mouse and human fibroblasts transduced with three (Oct4/Klf4/Sox2) or four (Oct4/Klf4/Sox2/cMyc) factors. Vitamin C can alleviate cell senescence by p53 repression and may accelerate reprogramming by synergizing with epigenetic regulators.

摘要

在本期《细胞-干细胞》杂志上，Esteban 等人（2009）报道称，维生素 C 增强了用三种（Oct4/Klf4/Sox2）或四种（Oct4/Klf4/Sox2/cMyc）因子转导的小鼠和人成纤维细胞的重编程效率。维生素 C 可以通过抑制 p53 来减轻细胞衰老，并通过与表观遗传调节剂协同作用来加速重编程。