Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
Cell Mol Life Sci. 2020 May;77(9):1771-1791. doi: 10.1007/s00018-019-03352-6. Epub 2019 Nov 1.
Stem cells can differentiate to diverse cell types in our body, and they hold great promises in both basic research and clinical therapies. For specific stem cell types, distinctive nutritional and signaling components are required to maintain the proliferation capacity and differentiation potential in cell culture. Various vitamins play essential roles in stem cell culture to modulate cell survival, proliferation and differentiation. Besides their common nutritional functions, specific vitamins are recently shown to modulate signal transduction and epigenetics. In this article, we will first review classical vitamin functions in both somatic and stem cell cultures. We will then focus on how stem cells could be modulated by vitamins beyond their nutritional roles. We believe that a better understanding of vitamin functions will significantly benefit stem cell research, and help realize their potentials in regenerative medicine.
干细胞可以在我们的体内分化为多种细胞类型，它们在基础研究和临床治疗中都有着巨大的潜力。对于特定的干细胞类型，需要独特的营养和信号成分来维持细胞培养中的增殖能力和分化潜能。各种维生素在干细胞培养中起着至关重要的作用，可以调节细胞的存活、增殖和分化。除了它们常见的营养功能外，最近还发现特定的维生素可以调节信号转导和表观遗传学。在本文中，我们将首先回顾经典维生素在体细胞和干细胞培养中的作用。然后，我们将重点讨论维生素如何在营养作用之外调节干细胞。我们相信，更好地了解维生素的作用将极大地有益于干细胞研究，并有助于实现它们在再生医学中的潜力。
