调控癌症干细胞的 miR 之路。
Regulating cancer stem cells the miR way.
机构信息
The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.
出版信息
Cell Stem Cell. 2010 Jan 8;6(1):4-6. doi: 10.1016/j.stem.2009.12.006.
PMID:20085735
Abstract
A recent study in Nature Cell Biology, Wellner et al. (2009) identifies ZEB1, a known promoter of tumor invasion, as a negative regulator of miRNA clusters that target stem cell factors. These findings provide new insight into the network of transcription factors and miRNAs that regulate cancer stem cells.
摘要
最近发表在《自然细胞生物学》上的一项研究中，Wellner 等人（2009 年）确定 ZEB1 为肿瘤侵袭的已知促进因子，也是靶向干细胞因子的 miRNA 簇的负调节剂。这些发现为调节癌症干细胞的转录因子和 miRNA 网络提供了新的见解。
Zotero 插件