TRRAP 在神经胶质瘤干性维持中的作用。
TRRAP and the maintenance of stemness in gliomas.
机构信息
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Cell Stem Cell. 2010 Jan 8;6(1):6-7. doi: 10.1016/j.stem.2009.12.005.
PMID:20085736
Abstract
Resistance of brain tumors to therapy and their eventual recurrence is attributed to stem-like cells. In this issue of Cell Stem Cell, a high-throughput kinome-wide screen (Wurdak et al., 2010) has identified TRRAP, a kinase-related protein, as being required for stem cell character in gliomas.
摘要
肿瘤对治疗的耐药性及其最终复发归因于干细胞样细胞。在本期《细胞—干细胞》杂志上，一项高通量激酶组全谱筛选（Wurdak 等人，2010）鉴定出 TRRAP 是神经胶质瘤干细胞特性所必需的一种激酶相关蛋白。
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