Department of Radiology, Graduate School of Medicine, Chiba University, Chiba-City, Chiba 260-8670, Japan.
Jpn J Clin Oncol. 2010 May;40(5):464-9. doi: 10.1093/jjco/hyp190. Epub 2010 Jan 18.
To examine the effects of dose-volume factors on the development of radiation pneumonitis in patients with non-small-cell lung cancer who received twice-daily radiotherapy concurrently with carboplatin and paclitaxel chemotherapy.
Radiotherapy consisted of twice-daily fractionation of 1.2 Gy, to a total dose of 60 Gy. Weekly carboplatin and paclitaxel were used as a concurrent chemotherapy. Effects of radiotherapy parameters on the development of radiation pneumonitis were retrospectively analyzed.
Fourteen of 37 patients developed Grade 2 or worse (> or = G2) radiation pneumonitis. Grade 2 or worse radiation pneumonitis occurred in all 5 patients with V5 >40%, all 4 patients with V10 >35%, all 4 patients with V13 >32%, 9 of 14 patients with V20 >24% and 8 of 11 patients with V30 >22%, whereas 9 of 32 patients with V5 <40%, 10 of 33 patients with V10 <35%, 10 of 33 patients with V13 <32%, 5 of 23 patients with V20 <24% and 6 of 26 patients with V30 <22%, with respective P values of 0.0045, 0.015, 0.015, 0.015 and 0.008. Eight of 11 patients with a mean lung dose of >14 Gy developed > or = G2 radiation pneumonitis in contrast to 6 of 26 patients with a mean lung dose of <14 Gy (P = 0.008).
Several cut-off values in the V(dose) and the mean lung dose differentiating probabilities of developing > or = G2 radiation pneumonitis were identified in this combination therapy.
研究非小细胞肺癌患者接受卡铂和紫杉醇化疗同步每日 2 次放疗时，剂量-体积因素对放射性肺炎发生的影响。
放疗采用 1.2Gy 每日 2 次分割，总剂量 60Gy。每周给予卡铂和紫杉醇同步化疗。回顾性分析放疗参数对放射性肺炎发生的影响。
37 例患者中有 14 例发生 2 级或更高级（>或=G2）放射性肺炎。5 例 V5 >40%、4 例 V10 >35%、4 例 V13 >32%、9 例 V20 >24%和 8 例 V30 >22%的患者均发生 2 级或更高级放射性肺炎，而 V5 <40%、V10 <35%、V13 <32%、V20 <24%和 V30 <22%的患者分别有 9、10、10、5 和 6 例发生 2 级或更高级放射性肺炎（P 值分别为 0.0045、0.015、0.015、0.015 和 0.008）。11 例平均肺剂量>14Gy 的患者中有 8 例发生>或=G2 放射性肺炎，而 26 例平均肺剂量<14Gy 的患者中仅有 6 例发生（P = 0.008）。
在该联合治疗中，V（剂量）和平均肺剂量的几个截断值可区分发生>或=G2 放射性肺炎的概率。
