NIH Clinical Center Pharmacy Department, 10 Center Drive, Bethesda, MD 20892, USA.
Antimicrob Agents Chemother. 2010 Apr;54(4):1633-5. doi: 10.1128/AAC.01438-09. Epub 2010 Jan 19.
We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC(pleural fluid)) to that in serum (AUC(serum)) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 microg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.
我们报告了 1 例肺毛霉病并脓胸患者中脂质体两性霉素 B 进入胸腔液的情况。24 小时内脂质体两性霉素 B 的胸腔液 AUC（AUC（胸腔液））与血清 AUC（AUC（血清））的比值为 9.4%，胸腔液浓度为 2.12 至 4.91μg/ml。鉴于脂质体两性霉素 B 进入胸腔液的水平相对较低，可能需要胸腔引流管来成功治疗毛霉性脓胸。
