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雾化脂质体两性霉素B在治疗烟曲霉脓胸中的应用。

Use of nebulised liposomal amphotericin B in the treatment of Aspergillus fumigatus empyema.

作者信息

Purcell I F, Corris P A

机构信息

Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne, UK.

出版信息

Thorax. 1995 Dec;50(12):1321-3. doi: 10.1136/thx.50.12.1321.

DOI:10.1136/thx.50.12.1321
PMID:8553311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1021361/
Abstract

A 28 year old man with asthma, bronchopulmonary aspergillosis, pulmonary thromboembolic disease, and pulmonary hypertension developed Aspergillus fumigatus empyema complicating a pneumothorax. His condition progressively deteriorated despite treatment with intravenous and intrapleural amphotericin B, but improved promptly after substituting nebulised liposomal amphotericin B and oral itraconazole. This experience suggests that nebulised liposomal amphotericin B is well tolerated and merits further assessment in the treatment of pulmonary fungal disease.

摘要

一名28岁男性，患有哮喘、支气管肺曲霉菌病、肺血栓栓塞性疾病和肺动脉高压，并发烟曲霉菌性脓胸和气胸。尽管接受了静脉和胸膜内两性霉素B治疗，但其病情仍逐渐恶化，但在改用雾化脂质体两性霉素B和口服伊曲康唑后迅速改善。这一经验表明，雾化脂质体两性霉素B耐受性良好，值得在肺部真菌病治疗中进一步评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a8a/1021361/50a2adf6ab7d/thorax00317-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a8a/1021361/50a2adf6ab7d/thorax00317-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a8a/1021361/50a2adf6ab7d/thorax00317-0106-a.jpg

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