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Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study.培美曲塞维持治疗联合最佳支持治疗与安慰剂联合最佳支持治疗用于非小细胞肺癌:一项随机、双盲、3期研究
Lancet. 2009 Oct 24;374(9699):1432-40. doi: 10.1016/S0140-6736(09)61497-5. Epub 2009 Sep 18.
2
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.吉非替尼或卡铂-紫杉醇用于治疗肺腺癌。
N Engl J Med. 2009 Sep 3;361(10):947-57. doi: 10.1056/NEJMoa0810699. Epub 2009 Aug 19.
3
Phase II study of pemetrexed and carboplatin plus bevacizumab with maintenance pemetrexed and bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer.培美曲塞、卡铂联合贝伐单抗一线治疗非鳞状非小细胞肺癌,继以培美曲塞和贝伐单抗维持治疗的II期研究。
J Clin Oncol. 2009 Jul 10;27(20):3284-9. doi: 10.1200/JCO.2008.20.8181. Epub 2009 May 11.
4
A novel five-antibody immunohistochemical test for subclassification of lung carcinoma.一种用于肺癌亚分类的新型五抗体免疫组织化学检测方法。
Mod Pathol. 2009 Aug;22(8):1032-43. doi: 10.1038/modpathol.2009.60. Epub 2009 May 8.
5
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial.西妥昔单抗联合化疗治疗晚期非小细胞肺癌患者(FLEX):一项开放标签的随机III期试验。
Lancet. 2009 May 2;373(9674):1525-31. doi: 10.1016/S0140-6736(09)60569-9.
6
Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials.化疗联合支持治疗可提高晚期非小细胞肺癌患者的生存率:一项对16项随机对照试验个体患者数据的系统评价和荟萃分析。
J Clin Oncol. 2008 Oct 1;26(28):4617-25. doi: 10.1200/JCO.2008.17.7162. Epub 2008 Aug 4.
7
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer.一项III期研究,比较顺铂加吉西他滨与顺铂加培美曲塞用于初治晚期非小细胞肺癌患者的化疗效果。
J Clin Oncol. 2008 Jul 20;26(21):3543-51. doi: 10.1200/JCO.2007.15.0375. Epub 2008 May 27.
8
Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features.在具有细支气管肺泡特征的肺腺癌中,黏液分化与表皮生长因子受体(EGFR)突变缺失及KRAS突变存在相关。
J Mol Diagn. 2007 Jul;9(3):320-6. doi: 10.2353/jmoldx.2007.060182.
9
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.KRAS突变是非小细胞肺癌中对表皮生长因子受体酪氨酸激酶抑制剂治疗耐药的重要预测指标。
Clin Cancer Res. 2007 May 15;13(10):2890-6. doi: 10.1158/1078-0432.CCR-06-3043.
10
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.单独使用紫杉醇-卡铂或联合贝伐单抗治疗非小细胞肺癌。
N Engl J Med. 2006 Dec 14;355(24):2542-50. doi: 10.1056/NEJMoa061884.

组织学很重要:个体化治疗非小细胞肺癌。

Histology matters: individualizing treatment in non-small cell lung cancer.

出版信息

Oncologist. 2010;15(1):3-5. doi: 10.1634/theoncologist.2009-0306. Epub 2010 Jan 19.

DOI:10.1634/theoncologist.2009-0306
PMID:20086166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3227884/
Abstract

This editorial discusses the role of histology in non-small cell lung cancer treatment.

摘要

这篇社论讨论了组织学在非小细胞肺癌治疗中的作用。