一个等位基因的缺失是另一个等位基因的获得：非小细胞肺癌中 NKX2-8 的改变。
One allele's loss is another's gain: alterations of NKX2-8 in non-small cell lung cancer.
机构信息
Stanford Cancer Center, Stanford, California, USA.
出版信息
Clin Cancer Res. 2011 Feb 15;17(4):638-9. doi: 10.1158/1078-0432.CCR-10-3081. Epub 2010 Dec 16.
Abstract
Large-scale genetic changes such as loss or gain of chromosomes are important drivers of solid tumor carcinogenesis. Recent technological advances in genomic profiling have allowed quantitative detection of gene copy numbers, leading to identification of the 14q13.3 gene locus as functionally important in non-small cell lung cancers.
摘要
大规模的遗传变化，如染色体的缺失或获得，是实体瘤致癌的重要驱动因素。近年来基因组分析技术的进步使基因拷贝数的定量检测成为可能，从而鉴定出非小细胞肺癌中 14q13.3 基因座在功能上的重要性。
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