Nakashima Yoko
Department of Human Nutrition, Seitoku University, Iwase, Matsudo, Chiba, Japan.
J Nutr Sci Vitaminol (Tokyo). 2009 Dec;55(6):498-505. doi: 10.3177/jnsv.55.498.
To investigate the causes why pups of dams fed a low-fat high-carbohydrate diet (LFD) showed strong preference for fat, two groups of pregnant rats were fed either the LFD or the control-diet (CTD) during pregnancy and lactation. After weaning, pups in both groups were divided into two groups. Two groups were offered a self-selection regimen of either a carbohydrate-protein diet (CPD) or a fat-protein diet (FPD) (the LFD-CF and the CTD-CF groups) and the remaining groups were fed the same diet as their dams (the LFD and the CTD groups) for 5 wk. Although the body weight of pups fed the LFD was lower than that of pups fed the CTD, the body weight of the LFD-CF group caught up with that of the CTD group. The ratio of FPD intake [FPD intake (g)/total intake (g)] by the LFD-CF group was higher than that of the CTD-CF group. In both dams and their pups, although no significant difference in the plasma glucose concentration was observed between the LFD and the CTD groups, the plasma insulin and triacylglycerol (TG) concentrations of the LFD group were higher than those of the CTD group. However, the self-selection diet appeared to prevent an increase in the plasma insulin and TG concentrations. Therefore, it was supposed that although pups of dams fed the LFD showed strong preference for fat in order to achieve optimal growth, the dietary selection pattern after weaning was associated with the depletion in plasma insulin.
为了探究喂食低脂高碳水化合物饮食（LFD）的母鼠所产幼崽对脂肪表现出强烈偏好的原因，两组怀孕大鼠在怀孕和哺乳期分别喂食LFD或对照饮食（CTD）。断奶后，两组幼崽均分为两组。两组被给予碳水化合物 - 蛋白质饮食（CPD）或脂肪 - 蛋白质饮食（FPD）的自选方案（LFD - CF组和CTD - CF组），其余组则喂食与母鼠相同的饮食（LFD组和CTD组），持续5周。尽管喂食LFD的幼崽体重低于喂食CTD的幼崽，但LFD - CF组的体重赶上了CTD组。LFD - CF组的FPD摄入量占比[FPD摄入量（克）/总摄入量（克）]高于CTD - CF组。在母鼠及其幼崽中，尽管LFD组和CTD组之间血浆葡萄糖浓度未观察到显著差异，但LFD组的血浆胰岛素和三酰甘油（TG）浓度高于CTD组。然而，自选饮食似乎可防止血浆胰岛素和TG浓度升高。因此，推测尽管喂食LFD的母鼠所产幼崽为实现最佳生长而对脂肪表现出强烈偏好，但断奶后的饮食选择模式与血浆胰岛素的消耗有关。
