Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country, Bilbao, Spain.
J Hypertens. 2010 Apr;28(4):723-31. doi: 10.1097/HJH.0b013e328336ecf3.
Several obesity phenotypes (e.g. body mass and fat, fat distribution) have been suggested to be a risk for elevated blood pressure. This study was undertaken to determine the heritability of four blood pressure phenotypes: SBP, DBP, pulse pressure (PP) and mean arterial pressure (MAP) and to assess the strength of genetic and environmental correlations among these phenotypes, and also between blood pressure and the different obesity-related traits.
The studied sample consisted of 429 nuclear families living in the Greater Bilbao (Spain) and included 1302 individuals aged 4-61 years. Univariate and bivariate quantitative genetic analyses were performed using a variance components procedure implemented in Sequential Oligogenic Linkage Analysis Routines software.
SBP, DBP, PP and MAP were significantly influenced by genetic factors with heritability estimates of 0.25, 0.28, 0.14 and 0.31, respectively, and presented high genetic and environmental correlations between them (except DBP-PP). On the contrary, whereas SBP, DBP and MAP showed common environmental factors with almost all body mass and fat-related traits, pleiotropic effects were only detected for some pairs, especially for those phenotypes that included skinfolds. In contrast, PP did not exhibit common genetic or environmental factors with obesity phenotypes in the studied population
Blood pressure and obesity phenotypes do not share, in general, a substantial influence of common genetic and environmental effects. Finally, the results obtained revealed the importance of the amount of adipose tissue in the genetic correlations with SBP, DBP and MAP, at least, during the growth period.
已有研究提出，多种肥胖表型（如体重和体脂、体脂分布）可能会增加血压升高的风险。本研究旨在确定四种血压表型（SBP、DBP、脉压（PP）和平均动脉压（MAP）的遗传率，并评估这些表型之间以及血压与不同肥胖相关特征之间的遗传和环境相关性的强度。
研究样本由居住在西班牙毕尔巴鄂大区的 429 个核心家庭组成，共包含 1302 名年龄在 4-61 岁之间的个体。采用方差分量程序在 Sequential Oligogenic Linkage Analysis Routines 软件中进行单变量和双变量数量遗传分析。
SBP、DBP、PP 和 MAP 均受到遗传因素的显著影响，遗传率估计值分别为 0.25、0.28、0.14 和 0.31，它们之间具有较高的遗传和环境相关性（除 DBP-PP 外）。相反，SBP、DBP 和 MAP 与几乎所有体重和体脂相关特征具有共同的环境因素，但仅在某些对中检测到多效性效应，尤其是那些包含皮褶的表型。相比之下，PP 在研究人群中与肥胖表型没有共同的遗传或环境因素。
一般来说，血压和肥胖表型没有共同的遗传和环境因素的显著影响。最后，研究结果表明，在生长期间，脂肪组织的数量至少对 SBP、DBP 和 MAP 的遗传相关性非常重要。
