妊娠期糖尿病——孕妇体重指数和血糖控制对婴儿出生体重的影响。

Gestational Diabetes Mellitus - the impact of maternal body mass index and glycaemic control on baby's birth weight.

作者信息

Krstevska B, Mishevska S, Janevska E, Simeonova S, Livrinova V, Pemovska G, Velkoska Nakova V, Serafimoski V

机构信息

Endocrinology, Diabetes and Metabolic Disorders Clinic, Medical Faculty, Skopje, R. Macedonia.

出版信息

Prilozi. 2009 Dec;30(2):115-24.

PMID:20087254

Abstract

OBJECTIVES

To asses the influence of the maternal BMI and glycaemic control in women with GDM on the baby's birth weight (BW).

MATERIAL AND METHODS

We analysed 180 women with GDM. Macrosomia has been defined as BW > 4000 gm, small for gestational age < 2700 gm and appropriate for gestational age between both. According to the baby s BW the pregnant women were divided into three groups: group 1 (G1) with BW < 2700 gm (n = 26); group 2 (G2) with BW between 2700 to 4000 gm (n = 117), and group 3 (G3) with BW > 4000 gm (n = 37). We also analysed BMI (kg/m2), HbA1c (%), PPG (mmol/L) and time of delivery (WG).

RESULTS

Comparisons between G1 and G2 showed: BMI (30.7 +/- 5 & 31 +/- 5.2; p < 0.7), HbA1c (6.4 +/- 0.8 & 5.1 +/- 0.8, p < 0.002), PPG (8.2 +/- 1.7 & 6.9 +/- 1.5, p < 0.02), time of delivery (35.2 +/- 3.8 & 38.6 +/- 1.5, p < 0.0001) and BW (2289 +/- 504 & 3474 +/- 334, p < 0.0001). Comparisons between G2 and G3 showed: BMI (31 +/- 5. 2 & 33.4 +/- 6.1; p < 0.02), HbA1c (5.2 +/- 1.1 & 6.4 +/- 2.3, p < 0.02), PPG (6.9 +/- 1.5 & 8.2 +/- 1.9, p < 0.02), time of delivery (38.6 +/- 1.5 & 39.3 +/- 1.4, p < 0.01) and BW (3474 +/- 334 & 4431 +/- 302, p < 0.0001). Comparisons between G1 and G3 showed the difference at delivery time and the baby's BW (p < 0.0001).

CONCLUSIONS

Maternal obesity and PPG contribute to macrosomia and also PPG to SGE.

摘要

目的

评估妊娠期糖尿病（GDM）女性的母体体重指数（BMI）和血糖控制对婴儿出生体重（BW）的影响。

材料与方法

我们分析了180例GDM女性。巨大儿定义为出生体重>4000克，小于胎龄儿<2700克，适于胎龄儿介于两者之间。根据婴儿出生体重，将孕妇分为三组：第1组（G1），出生体重<2700克（n = 26）；第2组（G2），出生体重在2700至4000克之间（n = 117）；第3组（G3），出生体重>4000克（n = 37）。我们还分析了BMI（千克/平方米）、糖化血红蛋白（HbA1c，%）、餐后血糖（PPG，毫摩尔/升）和分娩时间（孕周）。

结果

G1组与G2组比较显示：BMI（30.7±5与31±5.2；p<0.7）、HbA1c（6.4±0.8与5.1±0.8，p<0.002）、PPG（8.2±1.7与6.9±1.5，p<0.02）、分娩时间（35.2±3.8与38.6±1.5，p<0.0001）以及出生体重（2289±504与3474±334，p<0.0001）。G2组与G3组比较显示：BMI（31±5.2与33.4±6.1；p<0.02）、HbA1c（5.2±1.1与6.4±2.3，p<0.02）、PPG（6.9±1.5与8.2±1.9，p<0.02）、分娩时间（38.6±1.5与39.3±1.4，p<0.01）以及出生体重（3474±334与4431±302，p<0.0001）。G1组与G3组比较显示分娩时间和婴儿出生体重存在差异（p<0.0001）。