IE63 特异性 T 细胞应答与恶性肿瘤患者潜伏性水痘带状疱疹病毒再激活的临床控制相关。
IE63-specific T-cell responses associate with control of subclinical varicella zoster virus reactivation in individuals with malignancies.
机构信息
Department of Microbiology, University of Sri Jayawardanapura, Nugegoda, Sri Lanka.
出版信息
Br J Cancer. 2010 Feb 16;102(4):727-30. doi: 10.1038/sj.bjc.6605542. Epub 2010 Jan 19.
BACKGROUND
Reactivation of the varicella zoster virus (VZV) is more common in patients with malignancies; however, the molecular and cellular mechanisms underlying this susceptibility are unclear.
METHODS
Using ex vivo interferon-gamma ELISpot assays, we set out to analyse VZV-specific immune responses in a large cohort of patients with malignancies.
RESULTS
We observed that patients with malignancies had impaired VZV-specific T-cell responses, particularly in those with haematological malignancies and breast carcinoma. Immediate-early protein 63 (IE63)-specific T-cell responses were significantly impaired in those with subclinical VZV re-activation.
CONCLUSIONS
Our results suggest that T-cell responses to IE63 are important in controlling VZV replication.
背景
水痘带状疱疹病毒（VZV）的激活在恶性肿瘤患者中更为常见；然而，这种易感性的分子和细胞机制尚不清楚。
方法
使用体外干扰素-γ ELISpot 测定法，我们着手分析了恶性肿瘤患者的 VZV 特异性免疫反应。
结果
我们观察到恶性肿瘤患者的 VZV 特异性 T 细胞反应受损，特别是在血液恶性肿瘤和乳腺癌患者中。在有亚临床 VZV 再激活的患者中，早期蛋白 63（IE63）特异性 T 细胞反应显著受损。
结论
我们的结果表明，IE63 的 T 细胞反应对于控制 VZV 复制很重要。
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