Department of Neurophysiology, Max-Planck Institute for Brain Research, Frankfurt am Main, 60528, Germany.
Nat Rev Neurosci. 2010 Feb;11(2):100-13. doi: 10.1038/nrn2774.
Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (gamma-aminobutyric acid) interneurons and in cortico-cortical connections.
来自电生理学、生理学和解剖学研究的综合证据表明，神经元同步振荡活动的异常可能在精神分裂症的病理生理学中起核心作用。神经振荡是神经元反应之间建立精确时间关系的基本机制，而这与记忆、感知和意识有关。在精神分裂症患者中，β和γ波段活动的同步性异常，表明功能失调的振荡在产生认知缺陷和该疾病的其他症状方面起着关键作用。功能失调的振荡可能是由于 GABA（γ-氨基丁酸）中间神经元和皮质间连接的大脑节律产生网络的异常而产生的。
