Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Arch Gynecol Obstet. 2011 Feb;283(2):243-7. doi: 10.1007/s00404-010-1362-z. Epub 2010 Jan 20.
To determine maternal and fetal outcomes of women complicated with hyperthyroidism compared with those in normal pregnant women.
This cohort study was conducted on singleton pregnant women complicated by hyperthyroidism without other medical complications between January 1994 and December 2008, at tertiary center. The normal controls were identified to match the cases with the ratio of 2:1. The baseline characteristics as well as maternal and fetal outcomes were analyzed and compared for pregnancy outcomes.
Of the 203 pregnant women diagnosed for hyperthyroidism, 180 cases met the inclusion criteria, and 360 controls were matched. The activity of the disease was controlled to be euthyroid state in most cases. Maternal complications were comparable between both groups except that the study group had potentially higher incidence of pregnancy-induced hypertension. The mean gestational age (± SD), and mean birth weight were significantly lower in the study group. The incidence of fetal growth restriction, fetus with low birth weight and preterm births were significantly higher in the study group with a relative risk of 1.3, 1.4, and 1.3, respectively.
Pregnant women with hyperthyroidism were significantly associated with an increased risk of fetal growth restriction, preterm birth and low birth weight and had a tendency to have a higher rate of pregnancy-induced hypertension.
比较患有甲状腺功能亢进症的女性与正常孕妇的母婴结局。
本队列研究于 1994 年 1 月至 2008 年 12 月在三级中心进行，纳入了患有甲状腺功能亢进症且无其他合并症的单胎孕妇。以 2:1 的比例为病例匹配正常对照组。分析并比较了母婴结局，以评估妊娠结局。
在诊断为甲状腺功能亢进症的 203 名孕妇中，有 180 例符合纳入标准，匹配了 360 名对照组。大多数患者的疾病活动度控制在甲状腺功能正常状态。两组的母体并发症相当，但研究组妊娠高血压的发生率可能更高。研究组的平均孕龄（±标准差）和平均出生体重显著较低。研究组胎儿生长受限、低出生体重儿和早产的发生率显著升高，相对风险分别为 1.3、1.4 和 1.3。
患有甲状腺功能亢进症的孕妇与胎儿生长受限、早产和低出生体重的风险增加显著相关，且妊娠高血压的发生率有升高趋势。
