Lhermitte F, Marteau R, Chedru F, Mallecourt J, Estrade G, Godet-Guillain J, Chevallay M
Nouv Presse Med. 1977 Oct 22;6(35):3205-7.
A case of neuromyopathy due to chronic chloroquine intoxication is reported. The neuromyopathy developped 9 months after malaria suppression therapy with chloroquine was started. The clinical picture was that of a peripherical neuropathy in the lower limbs and of a generalized myasthenic syndrome. Muscular biopsy showed typical pictures of "vacuolar myopathy". The metabolism of the drug was normal. The patient improved soon after chloroquine was discontinued.
报告了一例因慢性氯喹中毒引起的神经肌肉病。神经肌肉病在开始用氯喹进行疟疾抑制治疗9个月后出现。临床表现为下肢周围神经病变和全身性肌无力综合征。肌肉活检显示“空泡性肌病”的典型表现。药物代谢正常。停用氯喹后患者很快好转。