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狂犬病病毒磷蛋白二聚化结构域。

Structure of the dimerization domain of the rabies virus phosphoprotein.

机构信息

UVHCI, UMI 3265 UJF-EMBL-CNRS, BP 181, 38042 Grenoble, Cedex 9, France.

出版信息

J Virol. 2010 Apr;84(7):3707-10. doi: 10.1128/JVI.02557-09. Epub 2010 Jan 20.

DOI:10.1128/JVI.02557-09
PMID:20089657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2838143/
Abstract

The crystal structure of the dimerization domain of rabies virus phosphoprotein was determined. The monomer consists of two alpha-helices that make a helical hairpin held together mainly by hydrophobic interactions. The monomer has a hydrophilic and a hydrophobic face, and in the dimer two monomers pack together through their hydrophobic surfaces. This structure is very different from the dimerization domain of the vesicular stomatitis virus phosphoprotein and also from the tetramerization domain of the Sendai virus phosphoprotein, suggesting that oligomerization is conserved but not structure.

摘要

狂犬病病毒磷蛋白二聚化结构域的晶体结构已被确定。单体由两个α螺旋组成，形成一个主要由疏水相互作用保持的发夹结构。单体具有亲水和疏水两个面，在二聚体中，两个单体通过疏水表面结合在一起。这种结构与水疱性口炎病毒磷蛋白的二聚化结构域以及仙台病毒磷蛋白的四聚化结构域非常不同，表明寡聚化是保守的，但结构不是。

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本文引用的文献

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Modular organization of rabies virus phosphoprotein.狂犬病病毒磷蛋白的模块化组织
J Mol Biol. 2009 May 22;388(5):978-96. doi: 10.1016/j.jmb.2009.03.061. Epub 2009 Mar 31.
2
Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein.水疱性口炎病毒磷蛋白C端核蛋白-RNA结合结构域的溶液结构
J Mol Biol. 2008 Oct 3;382(2):525-38. doi: 10.1016/j.jmb.2008.07.028. Epub 2008 Jul 16.
3
Unphosphorylated rhabdoviridae phosphoproteins form elongated dimers in solution.未磷酸化的弹状病毒科磷蛋白在溶液中形成细长的二聚体。
Biochemistry. 2007 Sep 11;46(36):10328-38. doi: 10.1021/bi7007799. Epub 2007 Aug 17.
4
Crystal structure of the rabies virus nucleoprotein-RNA complex.狂犬病病毒核蛋白-RNA复合物的晶体结构
Science. 2006 Jul 21;313(5785):360-3. doi: 10.1126/science.1125280. Epub 2006 Jun 15.
5
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6
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Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):449-57. doi: 10.1107/S0907444905001307. Epub 2005 Mar 24.
8
Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus.狂犬病病毒聚合酶辅助因子C末端结构域的结构与功能
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9
Refinement of macromolecular structures by the maximum-likelihood method.用最大似然法优化大分子结构。
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55. doi: 10.1107/S0907444996012255.
10
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Virology. 2004 Feb 20;319(2):201-11. doi: 10.1016/j.virol.2003.10.029.