狂犬病病毒磷蛋白二聚化结构域。
Structure of the dimerization domain of the rabies virus phosphoprotein.
机构信息
UVHCI, UMI 3265 UJF-EMBL-CNRS, BP 181, 38042 Grenoble, Cedex 9, France.
出版信息
J Virol. 2010 Apr;84(7):3707-10. doi: 10.1128/JVI.02557-09. Epub 2010 Jan 20.
Abstract
The crystal structure of the dimerization domain of rabies virus phosphoprotein was determined. The monomer consists of two alpha-helices that make a helical hairpin held together mainly by hydrophobic interactions. The monomer has a hydrophilic and a hydrophobic face, and in the dimer two monomers pack together through their hydrophobic surfaces. This structure is very different from the dimerization domain of the vesicular stomatitis virus phosphoprotein and also from the tetramerization domain of the Sendai virus phosphoprotein, suggesting that oligomerization is conserved but not structure.
摘要
狂犬病病毒磷蛋白二聚化结构域的晶体结构已被确定。单体由两个α螺旋组成，形成一个主要由疏水相互作用保持的发夹结构。单体具有亲水和疏水两个面，在二聚体中，两个单体通过疏水表面结合在一起。这种结构与水疱性口炎病毒磷蛋白的二聚化结构域以及仙台病毒磷蛋白的四聚化结构域非常不同，表明寡聚化是保守的，但结构不是。
相似文献
1
Structure of the dimerization domain of the rabies virus phosphoprotein.狂犬病病毒磷蛋白二聚化结构域。
J Virol. 2010 Apr;84(7):3707-10. doi: 10.1128/JVI.02557-09. Epub 2010 Jan 20.
2
Structure of the tetramerization domain of measles virus phosphoprotein.麻疹病毒磷蛋白四聚化结构域。
J Virol. 2013 Jun;87(12):7166-9. doi: 10.1128/JVI.00487-13. Epub 2013 Apr 10.
3
Vesicular Stomatitis Virus Phosphoprotein Dimerization Domain Is Dispensable for Virus Growth.水疱性口炎病毒磷蛋白二聚化结构域对于病毒生长并非必需。
J Virol. 2020 Feb 28;94(6). doi: 10.1128/JVI.01789-19.
4
Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus.水疱性口炎病毒磷蛋白寡聚化结构域的晶体结构
J Virol. 2006 Mar;80(6):2808-14. doi: 10.1128/JVI.80.6.2808-2814.2006.
5
Modular organization of rabies virus phosphoprotein.狂犬病病毒磷蛋白的模块化组织
J Mol Biol. 2009 May 22;388(5):978-96. doi: 10.1016/j.jmb.2009.03.061. Epub 2009 Mar 31.
6
Assignment of the 1H, 15N and 13C resonances of the nucleocapsid-binding domain of the Sendai virus phosphoprotein.仙台病毒磷蛋白核衣壳结合结构域的1H、15N和13C共振峰的归属
J Biomol NMR. 2001 Sep;21(1):75-6. doi: 10.1023/a:1011990021282.
7
Structural and Functional Characterization of the Phosphoprotein Central Domain of Spring Viremia of Carp Virus.鲤鱼春病毒血症病毒磷蛋白中央结构域的结构与功能分析。
J Virol. 2020 Jul 16;94(15). doi: 10.1128/JVI.00855-20.
8
Photolabeling identifies a putative fusion domain in the envelope glycoprotein of rabies and vesicular stomatitis viruses.光标记鉴定出狂犬病病毒和水疱性口炎病毒包膜糖蛋白中的一个假定融合结构域。
J Biol Chem. 1995 Jul 21;270(29):17575-81. doi: 10.1074/jbc.270.29.17575.
9
Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus.狂犬病病毒聚合酶辅助因子C末端结构域的结构与功能
J Mol Biol. 2004 Oct 29;343(4):819-31. doi: 10.1016/j.jmb.2004.08.071.
10
Biochemical and structural studies of the oligomerization domain of the Nipah virus phosphoprotein: evidence for an elongated coiled-coil homotrimer.尼帕病毒磷酸蛋白寡聚结构域的生化和结构研究：长型卷曲螺旋同三聚体的证据。
Virology. 2013 Nov;446(1-2):162-72. doi: 10.1016/j.virol.2013.07.031. Epub 2013 Aug 28.
引用本文的文献
1
Dynamic interactions of dimeric hub proteins underlie their diverse functions and structures: A comparative analysis of 14-3-3 and LC8.二聚体枢纽蛋白的动态相互作用构成其多样的功能和结构：14-3-3与LC8的比较分析
J Biol Chem. 2025 Apr;301(4):108416. doi: 10.1016/j.jbc.2025.108416. Epub 2025 Mar 17.
2
Dimerization of Rabies Virus Phosphoprotein and Phosphorylation of Its Nucleoprotein Enhance Their Binding Affinity.狂犬病病毒磷蛋白的二聚化及其核蛋白的磷酸化增强了它们的结合亲和力。
Viruses. 2024 Nov 4;16(11):1735. doi: 10.3390/v16111735.
3
Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex.澳大利亚蝙蝠狂犬病病毒核蛋白和磷蛋白复合物的结构测定。
Viruses. 2023 Dec 23;16(1):33. doi: 10.3390/v16010033.
4
Structural and biophysical characterization of the Borna disease virus 1 phosphoprotein.博尔纳病病毒 1 磷蛋白的结构和生物物理特性分析。
Acta Crystallogr F Struct Biol Commun. 2023 Mar 1;79(Pt 3):51-60. doi: 10.1107/S2053230X23000717. Epub 2023 Feb 23.
5
Structure and Dynamics of the Unassembled Nucleoprotein of Rabies Virus in Complex with Its Phosphoprotein Chaperone Module.狂犬病病毒非组装核蛋白与其磷蛋白伴侣模块复合物的结构与动态。
Viruses. 2022 Dec 16;14(12):2813. doi: 10.3390/v14122813.
6
Properties of rabies virus phosphoprotein and nucleoprotein biocondensates formed in vitro and in cellulo.狂犬病毒磷蛋白和核蛋白生物凝聚物的性质，在体外和细胞内形成。
PLoS Pathog. 2022 Dec 8;18(12):e1011022. doi: 10.1371/journal.ppat.1011022. eCollection 2022 Dec.
7
Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing.博尔纳病病毒 1 磷蛋白形成四聚体并与参与 DNA 双链断裂修复和 mRNA 加工的宿主因子相互作用。
Viruses. 2022 Oct 26;14(11):2358. doi: 10.3390/v14112358.
8
Molecular Basis of Functional Effects of Phosphorylation of the C-Terminal Domain of the Rabies Virus P Protein.狂犬病病毒 P 蛋白 C 末端结构域磷酸化的功能效应的分子基础。
J Virol. 2022 May 11;96(9):e0011122. doi: 10.1128/jvi.00111-22. Epub 2022 Apr 11.
9
Poorly Conserved P15 Proteins of Cileviruses Retain Elements of Common Ancestry and Putative Functionality: A Theoretical Assessment on the Evolution of Cilevirus Genomes.西病毒属中保守性较差的P15蛋白保留了共同祖先的元素和假定的功能：关于西病毒属基因组进化的理论评估
Front Plant Sci. 2021 Nov 5;12:771983. doi: 10.3389/fpls.2021.771983. eCollection 2021.
10
Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes.呼吸道合胞病毒 RNA 合成复合物的结构见解。
Viruses. 2021 May 5;13(5):834. doi: 10.3390/v13050834.
本文引用的文献
1
Modular organization of rabies virus phosphoprotein.狂犬病病毒磷蛋白的模块化组织
J Mol Biol. 2009 May 22;388(5):978-96. doi: 10.1016/j.jmb.2009.03.061. Epub 2009 Mar 31.
2
Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein.水疱性口炎病毒磷蛋白C端核蛋白-RNA结合结构域的溶液结构
J Mol Biol. 2008 Oct 3;382(2):525-38. doi: 10.1016/j.jmb.2008.07.028. Epub 2008 Jul 16.
3
Unphosphorylated rhabdoviridae phosphoproteins form elongated dimers in solution.未磷酸化的弹状病毒科磷蛋白在溶液中形成细长的二聚体。
Biochemistry. 2007 Sep 11;46(36):10328-38. doi: 10.1021/bi7007799. Epub 2007 Aug 17.
4
Crystal structure of the rabies virus nucleoprotein-RNA complex.狂犬病病毒核蛋白-RNA复合物的晶体结构
Science. 2006 Jul 21;313(5785):360-3. doi: 10.1126/science.1125280. Epub 2006 Jun 15.
5
Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus.水疱性口炎病毒磷蛋白寡聚化结构域的晶体结构
J Virol. 2006 Mar;80(6):2808-14. doi: 10.1128/JVI.80.6.2808-2814.2006.
6
The FoldX web server: an online force field.FoldX网络服务器：一种在线力场。
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W382-8. doi: 10.1093/nar/gki387.
7
Auto-rickshaw: an automated crystal structure determination platform as an efficient tool for the validation of an X-ray diffraction experiment.自动人力车：一个自动化晶体结构测定平台，作为验证X射线衍射实验的有效工具。
Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):449-57. doi: 10.1107/S0907444905001307. Epub 2005 Mar 24.
8
Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus.狂犬病病毒聚合酶辅助因子C末端结构域的结构与功能
J Mol Biol. 2004 Oct 29;343(4):819-31. doi: 10.1016/j.jmb.2004.08.071.
9
Refinement of macromolecular structures by the maximum-likelihood method.用最大似然法优化大分子结构。
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55. doi: 10.1107/S0907444996012255.
10
Structure and dynamics of the nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution.仙台病毒磷蛋白核衣壳结合结构域在溶液中的结构与动力学
Virology. 2004 Feb 20;319(2):201-11. doi: 10.1016/j.virol.2003.10.029.
Zotero 插件