• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
cAMP-response element-binding protein (CREB) controls MSK1-mediated phosphorylation of histone H3 at the c-fos promoter in vitro.环腺苷酸反应元件结合蛋白 (CREB) 在体外控制 MSK1 介导的 c-fos 启动子上组蛋白 H3 的磷酸化。
J Biol Chem. 2010 Mar 26;285(13):9390-9401. doi: 10.1074/jbc.M109.057745. Epub 2010 Jan 20.
2
Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression.剪切应力介导的染色质重塑为基因表达的血流依赖性调控提供了分子基础。
Circ Res. 2003 Jul 25;93(2):155-61. doi: 10.1161/01.RES.0000080933.82105.29. Epub 2003 Jun 12.
3
Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1.紫外线B诱导的组蛋白H3丝氨酸28位点的磷酸化由丝裂原和应激激活蛋白激酶1介导。
J Biol Chem. 2001 Aug 31;276(35):33213-9. doi: 10.1074/jbc.M103973200. Epub 2001 Jul 5.
4
Phosphorylation of histone H2A inhibits transcription on chromatin templates.组蛋白H2A的磷酸化抑制染色质模板上的转录。
J Biol Chem. 2004 May 21;279(21):21866-72. doi: 10.1074/jbc.M400099200. Epub 2004 Mar 9.
5
The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.激酶MSK1和MSK2是表皮生长因子诱导而非肿瘤坏死因子诱导的组蛋白H3丝氨酸10磷酸化所必需的。
J Biol Chem. 2006 May 5;281(18):12521-5. doi: 10.1074/jbc.M513333200. Epub 2006 Mar 3.
6
Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis.类菌孢素氨基酸通过激活 p38/MSK1/CREB/c-Fos/AP-1 轴上调透明质酸合酶 2 来刺激透明质酸的分泌。
J Biol Chem. 2020 May 22;295(21):7274-7288. doi: 10.1074/jbc.RA119.011139. Epub 2020 Apr 13.
7
Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling.低剂量染料木黄酮通过丝裂原活化蛋白激酶和丝裂原及应激激活激酶1非基因组信号通路对转录因子启动子区域进行表观遗传调控。
Cell Commun Signal. 2016 Aug 31;14(1):18. doi: 10.1186/s12964-016-0141-2.
8
Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.通过前体离子扫描质谱法鉴定丝裂原和应激激活蛋白激酶1（MSK1）中的新磷酸化位点。
Biochem J. 2007 Mar 15;402(3):491-501. doi: 10.1042/BJ20061183.
9
MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression.MSK1 在调节 p21 基因表达中作为 p53 的转录共激活因子发挥作用。
Exp Mol Med. 2018 Oct 10;50(10):1-12. doi: 10.1038/s12276-018-0160-8.
10
Increased phosphorylation of histone H3 at serine 10 is involved in Epstein-Barr virus latent membrane protein-1-induced carcinogenesis of nasopharyngeal carcinoma.组蛋白 H3 丝氨酸 10 的磷酸化增加与 Epstein-Barr 病毒潜伏膜蛋白 1 诱导的鼻咽癌发生有关。
BMC Cancer. 2013 Mar 18;13:124. doi: 10.1186/1471-2407-13-124.

引用本文的文献

1
ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes.ROS 信号转导介导的新型生物学靶标： Brf1 和 RNA Pol III 基因。
Oxid Med Cell Longev. 2021 Oct 4;2021:5888432. doi: 10.1155/2021/5888432. eCollection 2021.
2
Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase.使用基于 CRISPR/Cas9 的染色质激酶对可编程的人类组蛋白磷酸化和基因激活。
Nat Commun. 2021 Feb 9;12(1):896. doi: 10.1038/s41467-021-21188-2.
3
Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration.有丝分裂原和应激激活蛋白激酶 1 介导酒精上调 Brf1 和 tRNA 基因的转录，导致表型改变。
Oxid Med Cell Longev. 2020 Jun 27;2020:2067959. doi: 10.1155/2020/2067959. eCollection 2020.
4
MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression.MSK1 在调节 p21 基因表达中作为 p53 的转录共激活因子发挥作用。
Exp Mol Med. 2018 Oct 10;50(10):1-12. doi: 10.1038/s12276-018-0160-8.
5
Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.TFIIIB亚基和RNA聚合酶III基因的异常表达与肝细胞癌相关。
Liver Res. 2017 Sep;1(2):112-120. doi: 10.1016/j.livres.2017.08.005. Epub 2017 Sep 9.
6
Cytomegalovirus latency and reactivation: recent insights into an age old problem.巨细胞病毒潜伏与再激活：对一个古老问题的最新见解
Rev Med Virol. 2016 Mar;26(2):75-89. doi: 10.1002/rmv.1862. Epub 2015 Nov 17.
7
The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators.RNA 结合复合物 NF45-NF90 和 NF45-NF110 与 c-fos 基因动态结合，并作为转录共激活因子发挥作用。
J Biol Chem. 2015 Oct 30;290(44):26832-45. doi: 10.1074/jbc.M115.688317. Epub 2015 Sep 17.
8
Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene.亚砷酸盐激活人血红素加氧酶-1基因转录过程中Nrf2与组蛋白H3丝氨酸10磷酸化的协同调控
Biochim Biophys Acta. 2015 Oct;1849(10):1277-88. doi: 10.1016/j.bbagrm.2015.08.004. Epub 2015 Aug 18.
9
Mitogen and stress activated kinases act co-operatively with CREB during the induction of human cytomegalovirus immediate-early gene expression from latency.在从潜伏状态诱导人巨细胞病毒立即早期基因表达的过程中，丝裂原和应激激活激酶与CREB协同发挥作用。
PLoS Pathog. 2014 Jun 12;10(6):e1004195. doi: 10.1371/journal.ppat.1004195. eCollection 2014 Jun.
10
β-agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms.β-激动剂通过非经典核串扰机制选择性调节骨骼肌细胞中的促炎基因表达。
PLoS One. 2014 Mar 6;9(6):e90649. doi: 10.1371/journal.pone.0090649. eCollection 2014.

本文引用的文献

1
Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro.不均一核核糖核蛋白R在体外增强天然构型的c-fos启动子的转录。
J Biol Chem. 2009 Aug 28;284(35):23472-80. doi: 10.1074/jbc.M109.013656. Epub 2009 Jul 6.
2
The versatile role of MSKs in transcriptional regulation.肌动蛋白丝结合蛋白在转录调控中的多功能作用。
Trends Biochem Sci. 2009 Jun;34(6):311-8. doi: 10.1016/j.tibs.2009.02.007. Epub 2009 May 21.
3
The dynamics of HMG protein-chromatin interactions in living cells.活细胞中HMG蛋白与染色质相互作用的动力学
Biochem Cell Biol. 2009 Feb;87(1):127-37. doi: 10.1139/O08-110.
4
Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes.Hog1丝裂原活化蛋白激酶将染色质重塑复合物招募至应激基因。
EMBO J. 2009 Feb 18;28(4):326-36. doi: 10.1038/emboj.2008.299. Epub 2009 Jan 15.
5
MSK activation and physiological roles.肌肉骨骼激活与生理作用。
Front Biosci. 2008 May 1;13:5866-79. doi: 10.2741/3122.
6
Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1.有丝分裂原通过三元复合因子Elk-1诱导ERK和MSK募集至SRE启动子复合物。
Nucleic Acids Res. 2008 May;36(8):2594-607. doi: 10.1093/nar/gkn099. Epub 2008 Mar 11.
7
DNA binding and phosphorylation induce conformational alterations in the kinase-inducible domain of CREB. Implications for the mechanism of transcription function.DNA结合和磷酸化诱导CREB激酶诱导结构域的构象改变。对转录功能机制的启示。
J Biol Chem. 2007 Jul 6;282(27):19872-83. doi: 10.1074/jbc.M701435200. Epub 2007 May 9.
8
Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.通过前体离子扫描质谱法鉴定丝裂原和应激激活蛋白激酶1（MSK1）中的新磷酸化位点。
Biochem J. 2007 Mar 15;402(3):491-501. doi: 10.1042/BJ20061183.
9
Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3.孕激素靶基因的诱导需要激活Erk和Msk激酶以及组蛋白H3的磷酸化。
Mol Cell. 2006 Nov 3;24(3):367-81. doi: 10.1016/j.molcel.2006.10.011.
10
Activated signal transduction kinases frequently occupy target genes.活化的信号转导激酶经常占据靶基因。
Science. 2006 Jul 28;313(5786):533-6. doi: 10.1126/science.1127677.

环腺苷酸反应元件结合蛋白 (CREB) 在体外控制 MSK1 介导的 c-fos 启动子上组蛋白 H3 的磷酸化。

cAMP-response element-binding protein (CREB) controls MSK1-mediated phosphorylation of histone H3 at the c-fos promoter in vitro.

机构信息

Department of Molecular Biology, Faculty of Medicine, Saitama Medical University, Saitama 350-0495.

Department of Biochemistry, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan.

出版信息

J Biol Chem. 2010 Mar 26;285(13):9390-9401. doi: 10.1074/jbc.M109.057745. Epub 2010 Jan 20.

DOI:10.1074/jbc.M109.057745
PMID:20089855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2843188/
Abstract

The rapid induction of the c-fos gene correlates with phosphorylations of histone H3 and HMGN1 by mitogen- and stress-activated protein kinases. We have used a cell-free system to dissect the mechanism by which MSK1 phosphorylates histone H3 within the c-fos chromatin. Here, we show that the reconstituted c-fos chromatin presents a strong barrier to histone H3 phosphorylation by MSK1; however, the activators (serum response factor, Elk-1, cAMP-response element-binding protein (CREB), and ATF1) bound on their cognate sites recruit MSK1 to phosphorylate histone H3 at Ser-10 within the chromatin. This activator-dependent phosphorylation of histone H3 is enhanced by HMGN1 and occurs preferentially near the promoter region. Among the four activators, CREB plays a predominant role in MSK1-mediated phosphorylation of histone H3, and the phosphorylation of Ser-133 in CREB is essential for this process. Mutational analyses of MSK1 show that its N-terminal inhibition domain is critical for the kinase to phosphorylate chromatin-embedded histone H3 in a CREB-dependent manner, indicating the presence of an intricate regulatory network for MSK1-mediated phosphorylation of histone H3.

摘要

c-fos 基因的快速诱导与有丝分裂原和应激激活蛋白激酶对组蛋白 H3 和 HMGN1 的磷酸化有关。我们使用无细胞体系来剖析 MSK1 在 c-fos 染色质内磷酸化组蛋白 H3 的机制。在这里，我们表明，重新构建的 c-fos 染色质对 MSK1 磷酸化组蛋白 H3 具有很强的阻碍作用；然而，结合在其同源位点上的激活剂（血清反应因子、 Elk-1、cAMP 反应元件结合蛋白 (CREB) 和 ATF1）招募 MSK1 在染色质内的 Ser-10 处磷酸化组蛋白 H3。这种依赖于激活剂的组蛋白 H3 磷酸化被 HMGN1 增强，并优先发生在启动子区域附近。在这四个激活剂中，CREB 在 MSK1 介导的组蛋白 H3 磷酸化中起着主要作用，并且 CREB 中的 Ser-133 磷酸化对于该过程是必需的。对 MSK1 的突变分析表明，其 N 端抑制结构域对于激酶以 CREB 依赖性方式磷酸化染色质中嵌入的组蛋白 H3 至关重要，这表明存在一个复杂的调节网络来调节 MSK1 介导的组蛋白 H3 磷酸化。