Lippman S A, Sucupira M C A, Jones H E, Luppi C G, Palefsky J, van de Wijgert J H H M, Oliveira R L S, Diaz R S
Population Council, New York, NY, USA.
Int J STD AIDS. 2010 Feb;21(2):105-9. doi: 10.1258/ijsa.2009.008436.
We determined the prevalence, distribution and correlates of human papillomavirus (HPV) types in 386 mixed-income, sexually active women in São Paulo, Brazil. Endocervical samples were tested for HPV DNA with L1 primers MY09 and MY11; negative and indeterminate samples were retested using GP 5+/6+ consensus primers. HPV was detected in 35% of all women; high-risk/probable high-risk types in 20%; low-risk types in 7%; and an indeterminate type in 10%. Twenty-five HPV types were found overall: 17 (probable) high-risk types and eight low-risk types. Approximately one-third (29%) of women with HPV infection were positive for type 16 or 18 and 36% were positive for types 6, 11, 16 or 18. The presence of (probable) high-risk HPV was associated with younger age, more lifetime sex partners and abnormal vaginal flora. Additional studies mapping the distribution of HPV types worldwide are necessary to prepare for vaccination programmes and direct future vaccine development.
我们确定了巴西圣保罗386名不同收入水平、有性行为的女性中人类乳头瘤病毒（HPV）的流行情况、分布及相关因素。采用L1引物MY09和MY11对子宫颈内样本进行HPV DNA检测；对阴性和不确定样本使用GP 5+/6+通用引物重新检测。在所有女性中，35%检测出HPV；20%为高危/可能高危型；7%为低危型；10%为不确定型。共发现25种HPV类型：17种（可能）高危型和8种低危型。约三分之一（29%）感染HPV的女性16型或18型呈阳性，36%的女性6型、11型、16型或18型呈阳性。（可能）高危HPV的存在与年龄较小、性伴侣数量较多及阴道菌群异常有关。有必要开展更多研究以绘制全球HPV类型分布图，为疫苗接种计划做准备并指导未来疫苗研发。
