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本文引用的文献

1
Treating chronic pain: new knowledge, more choices.治疗慢性疼痛：新知识，更多选择。
Perm J. 2005 Fall;9(4):9-18. doi: 10.7812/TPP/05-067.
2
Is there epidemiologic evidence to support vascular disruption as a pathogenesis of gastroschisis?是否有流行病学证据支持血管破坏是腹裂的发病机制？
Am J Med Genet A. 2009 Jul;149A(7):1399-406. doi: 10.1002/ajmg.a.32897.
3
Management of RA medications in pregnant patients.妊娠患者类风湿关节炎药物的管理。
Nat Rev Rheumatol. 2009 Jul;5(7):382-90. doi: 10.1038/nrrheum.2009.103. Epub 2009 Jun 9.
4
Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes.孕期对乙酰氨基酚的使用与不良妊娠结局风险
Int J Epidemiol. 2009 Jun;38(3):706-14. doi: 10.1093/ije/dyp151. Epub 2009 Mar 30.
5
Use of a fentanyl patch throughout pregnancy.孕期全程使用芬太尼透皮贴剂。
J Obstet Gynaecol Can. 2009 Jan;31(1):20. doi: 10.1016/s1701-2163(16)34048-8.
6
Association of transdermal fentanyl and oral transmucosal fentanyl citrate in the treatment of opioid naive patients with severe chronic noncancer pain.透皮芬太尼与口服枸橼酸芬太尼口腔黏膜贴片联合用于治疗初次使用阿片类药物的重度慢性非癌性疼痛患者。
J Opioid Manag. 2008 Mar-Apr;4(2):111-5. doi: 10.5055/jom.2008.0016.
7
Aspirin and reproductive outcomes.阿司匹林与生殖结局。
Obstet Gynecol Surv. 2008 Jan;63(1):49-57. doi: 10.1097/OGX.0b013e31815e8731.
8
Neonatal abstinence syndrome and cerebral infarction following maternal codeine use during pregnancy.孕期母亲使用可待因后新生儿戒断综合征与脑梗死
Clin Pediatr (Phila). 2007 Sep;46(7):639-45. doi: 10.1177/0009922807300795.
9
Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis.孕晚期使用非甾体类抗炎药与动脉导管过早闭合的风险：一项荟萃分析
Ann Pharmacother. 2006 May;40(5):824-9. doi: 10.1345/aph.1G428. Epub 2006 Apr 25.
10
Prevalence of clinical hypertension in patients with chronic pain compared to nonpain general medical patients.慢性疼痛患者与非疼痛普通内科患者相比临床高血压的患病率。
Clin J Pain. 2005 Mar-Apr;21(2):147-53. doi: 10.1097/00002508-200503000-00006.

治疗孕期疼痛。

Treating pain during pregnancy.

出版信息

Can Fam Physician. 2010 Jan;56(1):25, 27.

PMID:20090076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2809170/
Abstract

QUESTION

My pregnant patients frequently ask about taking pain medications, sometimes for chronic conditions. What is known about the safety of using analgesics in therapeutic doses for acute or chronic pain during pregnancy?

ANSWER

Commonly prescribed pain medications appear to be relatively safe to use during pregnancy. None of the analgesics has been found to increase the risk of major malformations, although caution should be used when prescribing them in late pregnancy.

摘要

问题

我的孕妇患者经常询问使用止痛药的问题，有时是用于慢性疾病。对于在怀孕期间治疗急性或慢性疼痛时使用治疗剂量的镇痛药，其安全性有哪些已知信息？

答案

常用的处方止痛药在怀孕期间使用似乎相对安全。尚未发现任何一种镇痛药会增加主要畸形的风险，但在妊娠晚期使用时应谨慎。