Molecular Biology Laboratory, Division of Animal Biotechnology, Indian Veterinary Research Institute, Izatnagar, India.
Indian J Med Res. 2009 Nov;130(5):507-13.
Cancer is a major cause of deaths in humans. Though there has been significant progress in cancer therapy, the limited efficacy and toxicities of current chemo- and radiotherapies have provided an impetus for the search of new therapeutics. A therapeutic approach, which uses viruses for the treatment of cancer termed, oncolytic virotherapy has recently emerged. Newcastle disease virus (NDV) is one such virus with an inherent oncolytic property. NDV causes a highly infectious disease in poultry worldwide. In humans it is reported to have oncolytic and immuno-stimulatory effects. It specifically replicates in tumour cells while sparing normal cells and cause oncolysis. For many years different strains of the NDV have been investigated for treatment of various human cancers. Recent advances in reverse genetics provided investigators the tools to produce recombinant NDV with improved oncolytic property.
癌症是人类死亡的主要原因之一。尽管癌症治疗已经取得了重大进展，但目前化疗和放疗的疗效有限和毒性，促使人们寻找新的治疗方法。一种治疗方法是利用病毒治疗癌症，称为溶瘤病毒疗法，最近已经出现。新城疫病毒（NDV）就是这样一种具有内在溶瘤特性的病毒。NDV 在全球范围内导致家禽高度传染性疾病。据报道，它在人类中具有溶瘤和免疫刺激作用。它专门在肿瘤细胞中复制，而不伤害正常细胞，并导致肿瘤溶解。多年来，人们一直在研究 NDV 的不同菌株，以治疗各种人类癌症。反向遗传学的最新进展为研究人员提供了工具，以产生具有改善溶瘤特性的重组 NDV。
