Wu Yunzhou, Hao Jingbo, Li Deshan
Pharmaceutical Education and Research Office, School of Life Science, Northeast Agricultural University, Harbin 150030, China.
Sheng Wu Gong Cheng Xue Bao. 2010 Aug;26(8):1031-6.
Naturally existing Newcastle disease virus (NDV) can specifically execute oncolytic ability in clinical studies. Reports from clinical trials using NDV as oncolytic agents showed promise and warrant results in cancer therapy. In recent years, reverse genetics technology has been used widely in the studies of NDV virology. More recently, the technology was applied to optimize the oncolytic efficacy of NDV, for instance, modification of the F gene, and expression of GM-CSF, IFN-gamma, IL-2 or TNF-alpha. NDV is widely investigated in cancer therapy and will definitely offer a prosperous future for clinical cancer therapeutics. We reviewed the developments of cancer therapy by recombinant NDV using reverse genetics technology, as well as our own experience in this domain.
天然存在的新城疫病毒（NDV）在临床研究中可特异性发挥溶瘤能力。使用NDV作为溶瘤剂的临床试验报告显示出了前景，并为癌症治疗带来了值得期待的结果。近年来，反向遗传学技术已广泛应用于NDV病毒学研究。最近，该技术被用于优化NDV的溶瘤效果，例如修饰F基因，以及表达GM-CSF、IFN-γ、IL-2或TNF-α。NDV在癌症治疗方面受到广泛研究，必将为临床癌症治疗带来繁荣的未来。我们回顾了利用反向遗传学技术通过重组NDV进行癌症治疗的进展，以及我们在该领域的自身经验。
