Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Future Microbiol. 2012 Mar;7(3):347-67. doi: 10.2217/fmb.12.4.
Newcastle disease virus (NDV) is an avian paramyxovirus, which has been demonstrated to possess significant oncolytic activity against mammalian cancers. This review summarizes the research leading to the elucidation of the mechanisms of NDV-mediated oncolysis, as well as the development of novel oncolytic agents through the use of genetic engineering. Clinical trials utilizing NDV strains and NDV-based autologous tumor cell vaccines will expand our knowledge of these novel anticancer strategies and will ultimately result in the successful use of the virus in the clinical setting.
新城疫病毒（NDV）是一种禽副黏病毒，已被证明对哺乳动物癌症具有显著的溶瘤活性。本综述总结了阐明 NDV 介导的溶瘤机制的研究，以及通过基因工程开发新型溶瘤剂的研究。利用 NDV 株和基于 NDV 的自体肿瘤细胞疫苗进行的临床试验将扩大我们对这些新型抗癌策略的认识，并最终导致该病毒在临床环境中的成功应用。
