人体中胰高血糖素对胆汁的影响。
Biliary response to glucagon in humans.
作者信息
Branum G D, Bowers B A, Watters C R, Haebig J, Cucchiaro G, Farouk M, Meyers W C
机构信息
Department of Surgery, Duke University, Durham, North Carolina.
出版信息
Ann Surg. 1991 Apr;213(4):335-40. doi: 10.1097/00000658-199104000-00008.
Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.
已证明胰高血糖素对多种物种的胆汁分泌有深远影响。在胆道手术后的人体中研究了胰高血糖素的胆汁效应。9名患者接受了胆总管探查并插入了可球囊阻塞的T形管。保留采集样本的一部分，并通过经T形管远端端口回输采集的胆汁来维持肠肝循环。在胆汁酸输出稳定的情况下，胰高血糖素增加胆汁流量并降低胆固醇和磷脂输出。此外，胆汁酸谱的高效液相色谱分析显示，输注胰高血糖素后胆汁盐种类或结合情况无显著变化。胰高血糖素可能在人体胆汁分泌的生理调节中起重要作用。
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