胰岛素或胰高血糖素对离体灌注豚鼠肝脏胆汁分泌的影响。

Insulin or glucagon choleresis in the isolated perfused guinea pig liver.

作者信息

Meyers W C, Wellman C, Quarfordt S H, Jones R S

出版信息

Proc Soc Exp Biol Med. 1983 May;173(1):56-62. doi: 10.3181/00379727-173-41609.

Abstract

Insulin and glucagon choleresis was studied in an in situ, isolated perfused guinea pig liver system. Glucagon caused a small, significant increase in bile salt independent flow (1.83 +/- 0.19 to 2.02 +/- 0.23 microliter g-1 min-1), and dose-related increments over 2-16 micrograms were observed. Insulin alone had no choleretic effect. However, the combination of insulin and glucagon caused a response (1.89 +/- 0.15 to 2.42 +/- 0.19) greater than glucagon alone, and insulin stimulated choleresis when glucagon was present in substimulatory amounts. These observations demonstrate direct effects of glucagon and insulin upon the bile secretory apparatus. Glucagon directly stimulates choleresis, while insulin acts more subtly by potentiation with glucagon.

摘要

在原位分离灌注豚鼠肝脏系统中研究了胰岛素和胰高血糖素的利胆作用。胰高血糖素使不依赖胆盐的胆汁流量有小幅但显著的增加（从1.83±0.19微升·克⁻¹·分钟⁻¹增至2.02±0.23微升·克⁻¹·分钟⁻¹），并且观察到在2 - 16微克范围内呈剂量相关增加。单独使用胰岛素无利胆作用。然而，胰岛素与胰高血糖素联合使用引起的反应（从1.89±0.15增至2.42±0.19）大于单独使用胰高血糖素，并且当胰高血糖素处于亚刺激量时胰岛素可刺激胆汁分泌。这些观察结果证明了胰高血糖素和胰岛素对胆汁分泌装置的直接作用。胰高血糖素直接刺激胆汁分泌，而胰岛素通过与胰高血糖素协同作用发挥更微妙的作用。