Davitashvili D T, Museridze D P, Svanidze I K, Gegenava L G, Sanikidze T V
Georgian Med News. 2009 Dec(177):73-7.
The oxidative stress-induced changes and feasibility of prevention of these changes with an aid of vitamines E and C were investigated in cultured brain cortex of the newborn albino rats. Modeling the oxidative stress was achieved with addition of H(2)O(2) into the nutrient medium. In order to prevent an oxidative stress-induced cytotoxic effect, concomittantly with H(2)O(2), vitamines E and C were added into the nutrient medium. The data, obtained in our study revealed inhibition of the glial cells'- and axonal migration into the growth zone resulting from the oxidative stress. These changes were attenuated following action of vitamines E and C, which points at feasibility of their use against oxidative impact from the free radicals emerging during neurodegenerative disorders.
在新生白化大鼠的大脑皮层培养物中，研究了氧化应激诱导的变化以及借助维生素E和C预防这些变化的可行性。通过向营养培养基中添加H₂O₂来模拟氧化应激。为了预防氧化应激诱导的细胞毒性作用，在添加H₂O₂的同时，将维生素E和C添加到营养培养基中。我们的研究获得的数据显示，氧化应激导致神经胶质细胞和轴突向生长区的迁移受到抑制。维生素E和C作用后，这些变化减弱，这表明它们可用于对抗神经退行性疾病期间产生的自由基的氧化影响。
