Yang Mary Qu, Niemierko Andrzej, Yang Jack Y, Jin Yufang
Department of Health and Human Services, United States National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USA.
Int J Comput Biol Drug Des. 2009;2(3):207-20. doi: 10.1504/IJCBDD.2009.030113. Epub 2009 Dec 10.
Bioinformatics and systems biology are two booming research areas studying live organisms. Though having different focuses, bioinformatics and systems biology often share same or similar engineering and computer science methods to elucidate the mechanisms of multi-level biological systems. Regulatory mechanisms underlying biological processes involve interactions at cellular, sub-cellular, genomic and genetic levels. Accordingly, we need to bridge the gaps of biomedical researches at different levels of studies and foster the interdisciplinary and multidisciplinary research between both bioinformatics and systems biology domains. The synergic research on integrating bioinformatics and systems biology facilitates the advances in biology and medicine.
生物信息学和系统生物学是研究活生物体的两个蓬勃发展的研究领域。尽管侧重点不同，但生物信息学和系统生物学经常共享相同或相似的工程学和计算机科学方法来阐明多层次生物系统的机制。生物过程背后的调控机制涉及细胞、亚细胞、基因组和遗传水平的相互作用。因此，我们需要弥合不同研究层面上生物医学研究的差距，并促进生物信息学和系统生物学领域之间的跨学科和多学科研究。整合生物信息学和系统生物学的协同研究推动了生物学和医学的进步。
