Nomikos Michael, Philippou Prodromos, Glava Chrysa, Delakas Dimitrios
Department of Urology, "Asklipieion" General Hospital, Athens, Greece.
Cases J. 2009 Dec 22;2:9381. doi: 10.1186/1757-1626-2-9381.
Patients with neurogenic bladder due to spina bifida are considered to be at increased risk for aggressive bladder cancer. We present a unique case of a 32-year-old woman with spina bifida diagnosed with sarcomatoid urothelial carcinoma of the bladder and report diagnosis and management.
A 32 year old woman with neurogenic bladder managed with intermittent self catheterisations, presented with gross hematuria. On cystoscopy, she had a bulky bladder mass on the posterior bladder wall. Bladder biopsies revealed sarcomatoid variant of bladder transitional cell carcinoma. Treatment included radical cystectomy with ileal conduit diversion and adjuvant chemotherapy with excellent intermediate term follow up.
Patents with neurogenic bladder managed with intermittent self catheterisations need periodical follow up due to increased risk for aggressive bladder cancer. Immediate radical cystectomy with adjuvant chemotherapy is the suggested treatment approach.
因脊柱裂导致神经源性膀胱的患者被认为患侵袭性膀胱癌的风险增加。我们报告了一例独特的病例，一名32岁患有脊柱裂的女性被诊断为膀胱肉瘤样尿路上皮癌，并报告了诊断和治疗情况。
一名32岁患有神经源性膀胱且通过间歇性自我导尿进行治疗的女性出现肉眼血尿。膀胱镜检查时，她膀胱后壁有一个巨大的膀胱肿物。膀胱活检显示为膀胱移行细胞癌的肉瘤样变体。治疗包括根治性膀胱切除术及回肠导管改道，并进行辅助化疗，中期随访结果良好。
因脊柱裂导致神经源性膀胱且通过间歇性自我导尿进行治疗的患者，由于患侵袭性膀胱癌的风险增加，需要定期随访。建议的治疗方法是立即进行根治性膀胱切除术并辅以化疗。
