Solar Salt Biotechnology Research Center, Mokpo National University, Muan-gun, Jeonnam 534-729, Korea.
Nutr Res Pract. 2009 Fall;3(3):242-6. doi: 10.4162/nrp.2009.3.3.242. Epub 2009 Sep 30.
This study examined the anti-diabetic effect of onion (Allium cepa. Linn) in the streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into normal rats fed control diet or supplemented with onion powder (7% w/w) and diabetic rats fed control diet or supplemented with onion powder. Diabetes was induced by a single injection of STZ (60 mg/kg, ip) in citrate buffer. The animals were fed each of the experimental diet for 5 weeks. Blood glucose levels of rats supplemented with onion were lower than those of rats fed control diet in the diabetic rats. Onion also decreased the total serum lipid, triglyceride, and atherogenic index and increased HDL-cholesterol/total cholesterol ratio in the diabetic rats. Glutathione peroxidase, glutathione reductase and glutathione S-transferase activities were high in the diabetic rats compared to normal rats and reverted to near-control values by onion. These results indicate that onion decreased blood glucose, serum lipid levels and reduced renal oxidative stress in STZ-induced diabetic rats and this effect might exert the anti-diabetic effect of onion.
本研究考察了洋葱（Allium cepa. Linn）在链脲佐菌素（STZ）诱导的糖尿病大鼠中的降血糖作用。雄性 Sprague-Dawley 大鼠分为正常大鼠，给予对照饮食或补充洋葱粉（7%w/w），以及糖尿病大鼠，给予对照饮食或补充洋葱粉。糖尿病通过柠檬酸缓冲液中的单次 STZ（60mg/kg，ip）注射诱导。动物给予每种实验饮食 5 周。补充洋葱的大鼠的血糖水平低于糖尿病大鼠的对照饮食组。洋葱还降低了糖尿病大鼠的总血清脂质、甘油三酯和动脉粥样硬化指数，并增加了高密度脂蛋白胆固醇/总胆固醇的比值。与正常大鼠相比，糖尿病大鼠的谷胱甘肽过氧化物酶、谷胱甘肽还原酶和谷胱甘肽 S-转移酶活性较高，而洋葱则使其恢复到接近对照值。这些结果表明，洋葱可降低 STZ 诱导的糖尿病大鼠的血糖、血清脂质水平并减轻肾脏氧化应激，其降血糖作用可能归因于洋葱。
