Masood Sara, Rehman Attiq Ur, Bashir Shahid, El Shazly Mohamed, Imran Muhammad, Khalil Palwasha, Ifthikar Faiza, Jaffar Hafiza Madiha, Khursheed Tara
University Institute of Diet and Nutritional Sciences (UIDNS), Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
Horticulture Technologies, Production Systems Unit, Natural Resources Institute (Luke), Toivonlinnantie 518, FI-21500 Piikkiö, Finland.
J Diabetes Metab Disord. 2021 Mar 8;20(1):485-495. doi: 10.1007/s40200-021-00770-x. eCollection 2021 Jun.
Onion is one of the commonly cultivated and consumed vegetables rich in nutrients and phytochemicals. Various nutraceuticals are found in the outer fleshy layers and dry peel of onion which usually is treated as a common biowaste. Diabetes mellitus is a leading non communicable disease causing hyperglycemia and increased production of free radicals that potentially disrupts antioxidant enzymatic activity. Considering global consumption of wheat, the present study was designed to evaluate the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract (OPE) or onion powder (OP) on diabetic rats.
In this study, ethanolic extract of onion peel and onion bulb were prepared separately. Male Sprague Dawley rats were divided into 6 groups ( = 7). Different regimens of supplemented wheat bread (OPE (1% and 3%) and OP (5% and 7%)) were given to diabetic rats for eight weeks, plain bread was used as the control. Blood glucose level, body weight and activities of SOD, CAT, GPx, GR, GSH and MDA in the liver and kidney tissues were evaluated. Statistical analysis was performed using SPSS Version (25) and Dunnett's multiple comparison test.
Bread supplemented with 1% and 3% onion peel extract and 7% onion powder significantly reduced blood glucose levels and MDA in the treated rats compared with the control group diabetic rats. Body weight of diabetic rats was reduced for control group, while onion supplemented diet improved the body weight of treated rats. Onion supplementation also brought significant improvement in antioxidant enzyme activities among the treated diabetic rats.
These findings suggested that onion supplementation is effective in lowering blood glucose and could potentially aid in protecting organs from oxidative stress.
洋葱是常见的种植和食用蔬菜之一，富含营养物质和植物化学物质。洋葱的外层肉质层和干皮中含有多种营养保健品，而这些通常被视为普通生物废料。糖尿病是一种主要的非传染性疾病，会导致血糖升高和自由基产生增加，这可能会破坏抗氧化酶活性。考虑到小麦的全球消费量，本研究旨在评估添加洋葱皮提取物（OPE）或洋葱粉（OP）的小麦面包对糖尿病大鼠的降血糖和抗氧化作用。
在本研究中，分别制备了洋葱皮和洋葱鳞茎的乙醇提取物。将雄性Sprague Dawley大鼠分为6组（每组n = 7）。给糖尿病大鼠喂食不同配方的添加小麦面包（OPE（1%和3%）和OP（5%和7%）），为期8周，以普通面包作为对照。评估血糖水平、体重以及肝脏和肾脏组织中SOD、CAT、GPx、GR、GSH和MDA的活性。使用SPSS 25版软件和Dunnett多重比较检验进行统计分析。
与对照组糖尿病大鼠相比，添加1%和3%洋葱皮提取物以及7%洋葱粉的面包显著降低了治疗组大鼠的血糖水平和MDA含量。对照组糖尿病大鼠体重减轻，而添加洋葱的饮食改善了治疗组大鼠的体重。添加洋葱还使治疗组糖尿病大鼠的抗氧化酶活性有显著提高。
这些研究结果表明，添加洋葱有助于降低血糖，并可能有助于保护器官免受氧化应激的影响。
