Department of Pharmaceutical Science, University of Salerno, I-84084, Fisciano, Salerno, Italy.
Org Biomol Chem. 2010 Feb 7;8(3):622-7. doi: 10.1039/b918898c. Epub 2009 Dec 8.
An unusual and efficient method for the synthesis of new quinone-based amine and its derivatives from the corresponding alpha,alpha-amino ester is described. The procedure involves the quinone-based system's oxidative decarboxylation via hydride transfer throughout basic hydrolysis. This synthetic method provides, with good yields, rapid access to new potentially cytotoxic quinones.
描述了一种从相应的α，α-氨基酸酯合成新型醌基胺及其衍生物的独特而有效的方法。该方法涉及通过氢化物转移在碱性水解过程中醌基体系的氧化脱羧。这种合成方法以良好的收率提供了快速获得新型潜在细胞毒性醌的途径。
