Higashimori K, Nakamaru M, Tabuchi Y, Nagano M, Mikami H, Ogihara T, Inagami T
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Am J Hypertens. 1991 Jan;4(1 Pt 2):56S-59S. doi: 10.1093/ajh/4.1.56s.
The effects of angiotensin converting enzyme (ACE) inhibitors on the release of angiotensin II (Ang II) from isolated mesenteric arteries of spontaneously hypertensive rats (SHRs) were examined. Delapril, enalapril, and captopril suppressed Ang II release in a dose-dependent manner. After oral treatment with delapril (10 mg/kg/day), enalapril (10 mg/kg/day), and captopril (50 mg/kg/day) for 1 week, the blood pressure of SHRs was significantly reduced in the three groups and 54%, 46%, and 36% decreases in basal Ang II release were observed, respectively, compared with control. However, low-dose captopril (10 mg/kg/day) had no effect on blood pressure or basal Ang II release. These results provide clear evidence that ACE inhibitors suppress vascular renin-angiotensin activity of SHRs, and the possible contribution of the tissue renin-angiotensin system to spontaneous hypertension is suggested.
研究了血管紧张素转换酶（ACE）抑制剂对自发性高血压大鼠（SHR）离体肠系膜动脉中血管紧张素II（Ang II）释放的影响。地拉普利、依那普利和卡托普利以剂量依赖的方式抑制Ang II释放。在用10 mg/kg/天的地拉普利、10 mg/kg/天的依那普利和50 mg/kg/天的卡托普利口服治疗1周后，三组SHR的血压均显著降低，与对照组相比，基础Ang II释放分别降低了54%、46%和36%。然而，低剂量卡托普利（10 mg/kg/天）对血压或基础Ang II释放没有影响。这些结果提供了明确的证据，表明ACE抑制剂可抑制SHR的血管肾素-血管紧张素活性，并提示组织肾素-血管紧张素系统对自发性高血压可能有作用。
