Mizuno K, Niimura S, Tani M, Fukuchi S, Inagami T
Third Department of Internal Medicine, Fukushima Medical College, Japan.
Eur J Pharmacol. 1990 Aug 2;184(1):169-72. doi: 10.1016/0014-2999(90)90678-y.
The effect of the newly developed angiotensin-converting enzyme (ACE) inhibitor, delapril hydrochrolide (CV-3317), on the release of immunoreactive angiotensin II (irAng II) from isolated rat hind legs was compared with that of captopril. Both ACE inhibitors, added to the perfusion medium (2 X 10(-9) - 10(-6) M), suppressed irAng II release in a dose-dependent manner, but the inhibition was greater with delapril than with captopril. The results provide further support for the concept that vascular tissues produce Ang II and release it in a regulated fashion. The results also suggest a possible link between the antihypertensive mechanism of ACE inhibitors, including delapril, and the suppression of vascular Ang II release.
