蜂蜜用于治疗儿童急性咳嗽。
Honey for acute cough in children.
作者信息
Oduwole Olabisi, Meremikwu Martin M, Oyo-Ita Angela, Udoh Ekong E
机构信息
Institute of Tropical Diseases Research and Prevention, University of Calabar Teaching Hospital, EHCARP, P.O. Box 3134, General Post Office, Calabar, Cross River State, Nigeria.
出版信息
Cochrane Database Syst Rev. 2010 Jan 20(1):CD007094. doi: 10.1002/14651858.CD007094.pub2.
BACKGROUND
Cough causes concern for parents and is a major cause of outpatient visits. It can impact on quality of life, cause anxiety and affect sleep in parents and children. Several remedies, including honey, have been used to alleviate cough symptoms.
OBJECTIVES
To evaluate the effectiveness of honey for acute cough in children in ambulatory settings.
SEARCH STRATEGY
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, issue 2) which contains the Cochrane Acute Respiratory Infections Group's Specialised Register; MEDLINE (1950 to April Week 2 2009); EMBASE (1990 to April 2009); CINAHL (1982 to April 2009); Web of Science (2000 to April 2009); AMED (1985 to April 2009); and LILACS (1982 to April 2009).
SELECTION CRITERIA
Randomised controlled trials (RCT) comparing honey given alone or in combination with antibiotics versus nothing, placebo or other over-the-counter (OTC) cough medications to participants aged from two to 18 years for acute cough in ambulatory settings.
DATA COLLECTION AND ANALYSIS
Two review authors independently screened search results for eligible studies and extracted data on reported outcomes. Trial authors of the included study were contacted for additional information on unpublished data.
MAIN RESULTS
One RCT of 108 children with upper respiratory tract infections comparing the effect of honey, dextromethorphan and no treatment on cough and sleep quality for coughing children and their parents was included. Comparing symptoms and sleep quality scores of children that received honey with those that received no treatment showed that honey was more effective in reducing frequency of cough (mean difference (MD) -0.99; 95% CI -1.63 to -0.35, bothersome cough (MD -0.93; 95% CI -1.76 to -0.10), and sleep quality of the child (MD -0.92; 95% CI -1.77 to -0.07); but did not differ significantly between the honey versus no treatment groups in resolving severity of cough (MD -0.69; 95% CI -1.46 to 0.07) and sleep quality of the parents (MD 0.80; 95% CI -1.67 to 0.07). Dextromethorphan and honey did not differ significantly on cough frequency (MD -0.49; 95% CI -1.15 to 0.17); cough severity (MD -0.50; 95% CI -1.28 to 0.29), bothersome cough (MD -0.29; 95% CI -1.14 to 0.56) and sleep quality of the children (MD -0.70; 95% CI -1.57 to 0.17) or their parents (MD -0.34; 95% CI -1.24 to 0.55).
AUTHORS' CONCLUSIONS: We found insufficient evidence to advise for or against the use of honey for acute cough in children.
背景
咳嗽令家长担忧，是门诊就诊的主要原因。它会影响生活质量，引发焦虑，并影响家长和孩子的睡眠。包括蜂蜜在内的多种疗法已被用于缓解咳嗽症状。
目的
评估蜂蜜对门诊环境中儿童急性咳嗽的疗效。
检索策略
我们检索了Cochrane对照试验中心注册库（CENTRAL）（《Cochrane图书馆》2009年第2期），其中包含Cochrane急性呼吸道感染小组的专业注册库；MEDLINE（1950年至2009年4月第2周）；EMBASE（1990年至2009年4月）；CINAHL（1982年至2009年4月）；科学引文索引（2000年至2009年4月）；联合和补充医学数据库（1985年至2009年4月）；以及拉丁美洲和加勒比卫生科学数据库（1982年至2009年4月）。
选择标准
随机对照试验（RCT），比较单独使用蜂蜜或与抗生素联合使用与不使用、安慰剂或其他非处方（OTC）止咳药物，对2至18岁门诊环境中急性咳嗽参与者的疗效。
数据收集与分析
两位综述作者独立筛选检索结果以寻找符合条件的研究，并提取报告结局的数据。联系纳入研究的试验作者以获取未发表数据的更多信息。
主要结果
纳入一项针对108名上呼吸道感染儿童的随机对照试验，比较蜂蜜、右美沙芬和不治疗对咳嗽儿童及其家长咳嗽和睡眠质量的影响。将接受蜂蜜治疗的儿童与未接受治疗的儿童的症状和睡眠质量评分进行比较，结果显示蜂蜜在降低咳嗽频率（平均差（MD）-0.99；95%置信区间-1.63至-0.35）、烦扰性咳嗽（MD -0.93；95%置信区间-1.76至-0.10）以及儿童睡眠质量（MD -0.92；95%置信区间-1.77至-0.07）方面更有效；但在缓解咳嗽严重程度（MD -0.69；95%置信区间-1.46至0.07）和家长睡眠质量（MD 0.80；95%置信区间-1.67至0.07）方面，蜂蜜组与未治疗组之间无显著差异。右美沙芬和蜂蜜在咳嗽频率（MD -0.49；95%置信区间-1.15至0.17）、咳嗽严重程度（MD -0.50；95%置信区间-1.28至0.29）、烦扰性咳嗽（MD -0.29；95%置信区间-1.14至0.56）以及儿童（MD -0.70；95%置信区间-1.57至0.17）或其家长（MD -0.34；95%置信区间-1.24至0.55）的睡眠质量方面无显著差异。
作者结论
我们发现没有足够证据支持或反对在儿童急性咳嗽中使用蜂蜜。
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