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咳嗽:神经生理学、研究方法、药物治疗与言语听觉医学

Cough: neurophysiology, methods of research, pharmacological therapy and phonoaudiology.

作者信息

Balbani Aracy Pereira Silveira

机构信息

PhD in Medicine. Otorhinolaryngologist.

出版信息

Int Arch Otorhinolaryngol. 2012 Apr;16(2):259-68. doi: 10.7162/S1809-97772012000200016.

Abstract

INTRODUCTION

The cough is the more common respiratory symptom in children and adults.

OBJECTIVE

To present a revision on the neurophysiology and the methods for study of the consequence of the cough, as well as the pharmacotherapy and phonoaudiology therapy of the cough, based on the works published between 2005 and 2010 and indexed in the bases Medline, Lilacs and Library Cochrane under them to keywords "cough" or "anti-cough". Synthesis of the data: The consequence of the cough involves activation of receiving multiples becomes vacant in the aerial ways and of neural projections of the nucleus of the solitary treatment for other structures of the central nervous system. Experimental techniques allow studying the consequence of the cough to the cellular and molecular level to develop new anti-cough agents. It does not have evidences of that anti-cough exempt of medical lapsing they have superior effectiveness to the one of placebo for the relief of the cough. The phonoaudiology therapy can benefit patients with refractory chronic cough to the pharmacological treatment, over all when paradoxical movement of the vocal folds coexists. Final Comments: The boarding to multidiscipline has basic paper in the etiological diagnosis and treatment of the cough. The otolaryngologist must inform the patients on the risks of the anti-cough of free sales in order to prevent adverse poisonings and effect, especially in children.

摘要

引言

咳嗽是儿童和成人中较为常见的呼吸道症状。

目的

基于2005年至2010年间发表并在医学文献数据库Medline、Lilacs和考克兰图书馆中以关键词“咳嗽”或“止咳”索引的著作,对咳嗽的神经生理学、咳嗽后果的研究方法以及咳嗽的药物治疗和言语听觉治疗进行综述。

资料综合

咳嗽的后果涉及气道中多个感受器的激活以及孤束核向中枢神经系统其他结构的神经投射。实验技术能够在细胞和分子水平上研究咳嗽的后果,以开发新的止咳药物。没有证据表明无医疗差错的止咳药在缓解咳嗽方面比安慰剂更有效。言语听觉治疗可使对药物治疗无效的慢性顽固性咳嗽患者受益,尤其是当存在声带反常运动时。

最终评论

多学科方法在咳嗽的病因诊断和治疗中具有重要作用。耳鼻喉科医生必须告知患者非处方止咳药的风险,以防止不良中毒和影响,尤其是在儿童中。

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