Beck-Bornholdt H P, Omniczynski M, Theis E, Vogler H, Würschmidt F
Institute of Biophysics and Radiobiology, University of Hamburg, Germany.
Acta Oncol. 1991;30(1):57-63. doi: 10.3109/02841869109091814.
The aim of this work was to study influence of overall treatment time on response of an experimental tumour to fractionated radiotherapy. Rhabdomyosarcoma R1H of the rat was treated by fractionated irradiation applying 30 fractions in different overall treatment times of 10, 18.5, 29, 39, and 67 days. The doses per fraction ranged from 1.50 to 2.67 Gy. Tumour response was assessed by net growth delay and by an in vitro colony assay. The results indicate that repopulation of the tumour with clonogenic tumour cells slowed down during treatment leading to an average doubling time of clonogenic tumour cells of 8 +/- 1 days, which is considerably longer than that of unirradiated tumours (3 days). The repopulation rate seemed to increase after about 3 weeks of treatment with a doubling time of tumour clonogens of 5 +/- 1 days, which was still lower than in control tumours.
这项工作的目的是研究总治疗时间对实验性肿瘤对分割放疗反应的影响。采用分割照射对大鼠横纹肌肉瘤R1H进行治疗，在10、18.5、29、39和67天的不同总治疗时间内给予30次分割照射。每次分割剂量范围为1.50至2.67 Gy。通过净生长延迟和体外集落测定法评估肿瘤反应。结果表明，在治疗期间，具有克隆形成能力的肿瘤细胞的肿瘤再增殖减缓，导致克隆形成性肿瘤细胞的平均倍增时间为8±1天，这比未照射肿瘤的倍增时间（3天）长得多。在治疗约3周后，再增殖率似乎增加，肿瘤克隆原的倍增时间为5±1天，这仍低于对照肿瘤。
