Beck-Bornholdt H P, Maurer T, Becker S, Omniczynski M, Vogler H, Würschmidt F
Institut für Biophysik und Strahlenbiologie, University of Hamburg, F.R.G.
Int J Radiat Oncol Biol Phys. 1989 Mar;16(3):701-5. doi: 10.1016/0360-3016(89)90488-4.
The effect of a hyperfractionated irradiation treatment on the response of the rhabdomyosarcoma R1H of the rat was studied. Tumors were irradiated under ambient conditions with 126 fractions of X rays, applied in 3 fractions per day with a time interval of 8 +/- 1 hr between fractions on 7 days per week during 6 weeks. The total dose ranged from 54 to 90 Gy, that is the dose per fraction ranged from 0.43 to 0.71 Gy. Tumor response was assessed by tumor control probability and tumor net growth delay. The tumor response to the hyperfractionated treatment was found to be slightly more effective compared to the results obtained in a previous study where treatments with 6, 18, 30, and 42 fractions were applied. Since normal tissues are considerably spared with increased numbers of fractions, clinical studies with hyperfractionation seem to be very promising.
研究了超分割照射治疗对大鼠横纹肌肉瘤R1H反应的影响。在环境条件下，用126次X射线分割照射肿瘤，每周7天，每天分3次照射，每次分割间隔8±1小时，持续6周。总剂量范围为54至90 Gy，即每次分割剂量范围为0.43至0.71 Gy。通过肿瘤控制概率和肿瘤净生长延迟评估肿瘤反应。与先前研究中应用6、18、30和42次分割治疗的结果相比，发现超分割治疗的肿瘤反应略更有效。由于随着分割次数增加正常组织得到相当程度的保护，超分割的临床研究似乎非常有前景。
