Barcelona Science Park, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Org Lett. 2010 Feb 19;12(4):860-3. doi: 10.1021/ol902913j.
Unsaturated lactams with endo- or exocyclic C-C double bonds constitute a set of reactive inputs that serve as the electron-rich olefin component in Povarov reactions. These substrates afford the multicomponent adducts in convenient yields and offer a wide range of structural diversity. Postcondensation transformations allow direct access to a variety of lactam-fused and amide-substituted quinoline derivatives.
具有内或外环 C-C 双键的不饱和内酰胺构成了一组反应性输入物，它们作为 Povarov 反应中的富电子烯烃组分。这些底物以方便的产率提供多组分加合物，并提供广泛的结构多样性。后缩合转化允许直接获得各种酰胺取代的内酰胺稠合和酰胺取代的喹啉衍生物。
