通过铜催化的级联反应合成氮杂稠合多环喹啉。

Synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reactions.

机构信息

Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Science Park, Guangzhou, China, 510530.

出版信息

Org Lett. 2010 Apr 2;12(7):1500-3. doi: 10.1021/ol1002225.

DOI:10.1021/ol1002225

PMID:20196570

Abstract

A new and efficient method for the synthesis of aza-fused polycyclic quinolines (e.g., benzimidazo[1,2-a]quinolines) is described. This protocol includes an intermolecular condensation followed by a copper-catalyzed intramolecular C-N coupling reaction. The method is applied to a wide range of 2-iodo, 2-bromo, and 2-chloro aryl aldehyde substrates to yield the aza-fused polycyclic quinolines in good yields.

摘要

描述了一种用于合成氮杂稠合多环喹啉（例如苯并咪唑[1,2-a]喹啉）的新的有效方法。该方案包括分子间缩合，然后进行铜催化的分子内 C-N 偶联反应。该方法适用于多种 2-碘、2-溴和 2-氯芳基醛底物，以高产率得到氮杂稠合多环喹啉。