Erel O, Cannon T D, Hollister J M, Mednick S A, Parnas J
Department of Psychology, University of Southern California, Los Angeles 90089-1061.
Schizophr Res. 1991 Jan-Feb;4(1):49-52. doi: 10.1016/0920-9964(91)90009-g.
Using a subsample of subjects from the Copenhagen schizophrenia high-risk project, this study examined the relationship between ventricular enlargement and prospectively assessed deficits in premorbid school/occupational adjustment. Subjects with enlarged ventricles evidenced poorer premorbid school-occupational adjustment across three times of measurement spanning a period of 10 years. This effect was independent of the age and sex of the subjects and remained significant after controlling for psychiatric diagnosis. The results provide prospective evidence for an association between ventricular enlargement and poor premorbid history.
本研究利用哥本哈根精神分裂症高危项目中的部分受试者样本，考察了脑室扩大与病前学校/职业适应方面经前瞻性评估的缺陷之间的关系。脑室扩大的受试者在长达10年的三次测量中，均显示出病前学校职业适应较差。这种影响独立于受试者的年龄和性别，在控制了精神疾病诊断后仍具有显著性。研究结果为脑室扩大与不良病前史之间的关联提供了前瞻性证据。
