Elledge Ross O C, Khazaee-Farid Rokhsareh, Walker Rachel J, Sundaram Karthikeyan, Monaghan Andrew
Department of Oral and Maxillofacial Surgery, Royal Shrewsbury Hospital, Mytton Oak Road, Shrewsbury SY3 8XQ, Shropshire, United Kingdom.
Br J Oral Maxillofac Surg. 2011 Jan;49(1):42-6. doi: 10.1016/j.bjoms.2009.12.010. Epub 2010 Jan 25.
Our aim was to investigate the incidence of oral cancer in three ethnic groups, Indian, Pakistani, and Bangladeshi residents of the UK, to try to establish a link between ethnic background and the incidence of oral cancer. We used data from the 1991 and 2001 censuses to calculate approximate percentages of the number of Indian, Pakistani, and Bangladeshi residents in each Health Authority (HA) region and correlated these with rates of oral cancer from the Office of National Statistics (ONS) cancer atlas for the same period. Data about lung cancer and oesophageal cancer were used as proxies for the confounding variables of smoking and alcohol, respectively, in a multiple regression analysis. There was a strong significant correlation between figures for lung cancer and variations in oral cancer rates among HAs (p<0.001). Ethnicity contributed weakly and insignificantly to variations in rates of oral cancer among HAs. In summary, we found only a weak correlation between ethnicity and oral cancer in the UK population, unlike previously published studies, while simultaneously showing a stronger relation with the proxy for smoking trends. There are various drawbacks inherent in library-based ecological studies in general, and in this study in particular, that may have been responsible for this.
我们的目的是调查英国印度裔、巴基斯坦裔和孟加拉裔这三个族群的口腔癌发病率，试图建立种族背景与口腔癌发病率之间的联系。我们利用1991年和2001年人口普查的数据，计算每个卫生当局（HA）区域内印度裔、巴基斯坦裔和孟加拉裔居民数量的大致百分比，并将这些数据与同期国家统计局（ONS）癌症地图中的口腔癌发病率相关联。在多元回归分析中，分别将肺癌和食管癌的数据用作吸烟和饮酒这两个混杂变量的替代指标。肺癌数据与各卫生当局之间口腔癌发病率的变化存在很强的显著相关性（p<0.001）。种族因素对各卫生当局之间口腔癌发病率变化的影响微弱且不显著。总之，与之前发表的研究不同，我们发现英国人群中种族与口腔癌之间的相关性较弱，同时显示出与吸烟趋势替代指标的更强关联。一般而言，基于图书馆的生态学研究存在各种固有缺陷，本研究尤其如此，这可能是造成这种情况的原因。
